Flavones and Lignans from the Stems of Wikstroemia scytophylla Diels

• Published in: Pharmacognosy Magazine 2017-07, Vol.13 (51), p.488-491
• Main Authors: Lei, Jie-Ping, Yuan, Juan-Juan, Pi, Sheng-Hao, Wang, Rui, Tan, Rui, Ma, Chao-Ying, Zhang, Tao, Jiang, He-Zhong
• Format: Article
• Language: English
• Subjects: Bioassays; Breast cancer; Chemical properties; Cytotoxicity; Engineering; Flavonoids; Health aspects; Life sciences; Medicinal plants; Methods; NMR; Nuclear magnetic resonance; Original; Pharmacognosy; Studies
• ISSN: 0973-1296; 0976-4062
• DOI: 10.4103/pm.pm_275_16

The genus has about 70 species, but only a limited number of species have been studied chemically. indica has long been used as a traditional crude drug in China. However, there is no report about the bioactivity of . This paper reports the chemical investigation and biological evaluation of the . The EtOAc extraction of was isolated using chromatographic methods, and the compounds were analyzed by spectroscopic methods. The antitumor activities against five human cancer cell lines were performed according to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. The chemical investigation of the stems of resulted in the isolation of 12 compounds mainly including one biflavone (1), five flavones (2-6) compounds, and six lignans (7-12), in which compound 8 was a new natural product. Compounds 1 and 7-12 were evaluated for their antitumor activities while these compounds showed weak cytotoxicity with the half maximal inhibitory (IC ) values more than 40 μM. All of these compounds were isolated from this plant for the first time, and compounds 2-12 were first reported from genus , in which compound 8 was a new natural product. Compounds 1 and 7-12 exhibited weak antitumor activities (IC >40 μM). The chemotaxonomic significance of all the isolations was summarized. The chemical investigation of the stems of W. scytophylla resulted in the isolation of 12 compoundsThe 12 compounds including six lignans (7-12), in which compound 8 was a new natural productThe isolated compounds 1 and 7-12 were evaluated for their antitumor activitiesThe chemotaxonomic significance of all the isolations was summarized. MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; IC50: Half maximal inhibitory; HL-60: Human leukemia cell line; SMMC-7721: Human hepatocellular carcinoma cell line; A549: Human lung tumor cell line; MCF-7: Human breast cancer cell line; SW480: Human colon cancer cell line; MS: Mass spectrometry; NMR: Nuclear Magnetic Resonance.