Migraine as a sex-conditioned inherited disorder: evidences from China and the world

Migraine is a complex and heterogeneous disorder. Although several genetic models has been proposed including autosomal-dominant/autosomal recessive, sex-linked, sex-limited, mitochondrial, and multi-gene, none of these models can well-explain the transmission of the disease. We hypothesied that mig...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience bulletin 2008-04, Vol.24 (2), p.110-116
Main Authors: Wang, Xiao-Ping, Ding, Hong-Liu, Geng, Chang-Ming, Jiang, Yu-Mei
Format: Article
Language:English
Subjects:
Age of Onset
Anatomy
Anesthesiology
Biomedical and Life Sciences
Biomedicine
China - epidemiology
Female
Genes, Dominant - genetics
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Gonadal Steroid Hormones - metabolism
Human Physiology
Humans
Inheritance Patterns - genetics
Male
Menstrual Cycle - genetics
Migraine Disorders - epidemiology
Migraine Disorders - genetics
Minireview
Neurology
Neurosciences
Pain Medicine
Sex Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Migraine is a complex and heterogeneous disorder. Although several genetic models has been proposed including autosomal-dominant/autosomal recessive, sex-linked, sex-limited, mitochondrial, and multi-gene, none of these models can well-explain the transmission of the disease. We hypothesied that migraine is a sex-conditioned inherited disorder (autosomal dominant in females and autosomal recessive in males). This hypothesis is supported by the evidence such as the locations of genes associated with familial hemiplegic migraine, possibly “typical” migraine as well (dominantly on chromosome 19p, 1q, and 2q), male:female ratio of prevalence (1:2–1:4), the mostly youth-onset, the provocation by the contraceptives, the induction by menstruation, and the self-limitation after menopause. Female sex-hormones appear to be the key contributor to a higher prevalence of migraine in female. Socio-environmental factors may also play an important role.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-008-0110-x