Fibrillin-2 and Tenascin-C bridge the age gap in lung epithelial regeneration

Organ engineering based on native matrix scaffolds involves combining regenerative cell populations with corresponding biological matrices to form functional grafts on-demand. The extracellular matrix (ECM) that is retained following lung decellularization provides essential structure and biophysica...

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Bibliographic Details
Published in:Biomaterials 2017-09, Vol.140, p.212-219
Main Authors: Gilpin, Sarah E., Li, Qiyao, Evangelista-Leite, Daniele, Ren, Xi, Reinhardt, Dieter P., Frey, Brian L., Ott, Harald C.
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation
Cells, Cultured
Decellularization
Epithelium
Extracellular matrix
Extracellular Matrix - chemistry
Extracellular Matrix - metabolism
Fibrillin-2 - chemistry
Fibrillin-2 - metabolism
Humans
Infant
Lung
Lung - chemistry
Lung - cytology
Lung - physiology
Middle Aged
Rats
Re-Epithelialization
Regeneration
Tenascin - chemistry
Tenascin - metabolism
Tissue Engineering
Tissue Scaffolds - chemistry
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Summary:Organ engineering based on native matrix scaffolds involves combining regenerative cell populations with corresponding biological matrices to form functional grafts on-demand. The extracellular matrix (ECM) that is retained following lung decellularization provides essential structure and biophysical cues for whole organ regeneration after recellularization. The unique ECM composition in the early post-natal lung, during active alveologenesis, may possess distinct signals that aid in driving cell adhesion, survival, and proliferation. We evaluated the behavior of basal epithelial stem cells (BESCs) isolated from adult human lung tissue, when cultured on acellular ECM derived from neonatal (aged 
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2017.06.027