Simplifying Profiles of Comorbidity in Bipolar Disorder

Abstract Background Comorbid psychiatric symptoms in bipolar disorder (BD) predict poorer course of illness and treatment outcome. The sheer number of comorbid symptoms has thwarted developing treatments to address these comorbid concerns. The goal of this study was to develop a more parsimonious ap...

Full description

Saved in:
Bibliographic Details
Published in:Journal of affective disorders 2017-10, Vol.220, p.102-107
Main Authors: Eisner, Lori R, Johnson, Sheri L, Youngstrom, Eric A, Pearlstein, Jennifer G
Format: Article
Language:English
Subjects:
Adult
Affect
Alcoholism - epidemiology
Anxiety disorders
Anxiety Disorders - epidemiology
Bipolar disorder
Bipolar Disorder - epidemiology
Bipolar Disorder - psychology
Comorbidity
Diagnostic and Statistical Manual of Mental Disorders
Dimensional
Female
Humans
Male
Mental Disorders - epidemiology
Mental Disorders - psychology
Middle Aged
Personality Disorders - epidemiology
Prevalence
Psychiatric Status Rating Scales
Psychiatry
Statistics as Topic
Substance use disorders
Surveys and Questionnaires
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Comorbid psychiatric symptoms in bipolar disorder (BD) predict poorer course of illness and treatment outcome. The sheer number of comorbid symptoms has thwarted developing treatments to address these comorbid concerns. The goal of this study was to develop a more parsimonious approach to understanding clusters of comorbid symptoms within BD. Method Data were collected as part of the National Epidemiologic Survey on Alcohol and Related Conditions. Structured diagnostic interviews were conducted with 43,093 participants using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV (AUDADIS-IV). Analyses were conducted on lifetime symptom counts for the most common 14 comorbid disorders among the 1,411 persons who met lifetime criteria for bipolar I disorder. Results An exploratory factor analysis with promax rotation as well as confirmatory factor analyses revealed a three-factor solution of Externalizing, Anxiety, and Mood syndromes, with a higher order Internalizing factor comprised of the Mood and Anxiety factors. Limitations: Further research is needed in a clinical sample. Conclusions Comorbid symptoms in BD tend to cohere into Internalizing and Externalizing disorders, which could simplify research and treatment on comorbidity in BD.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2017.05.045