Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from resting tissues. More recently understood is that this metabolic phenotype is not unique to cancer cells but instead reflects characteristics of proliferating cells. Similar metabolic transitions also occu...

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Bibliographic Details
Published in:Cell metabolism 2017-07, Vol.26 (1), p.49-70
Main Authors: Andrejeva, Gabriela, Rathmell, Jeffrey C.
Format: Article
Language:English
Subjects:
Animals
antitumor immunity
Cell Proliferation
Glycolysis
Humans
Immunity
Immunity, Cellular
inflammation
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
macrophage
Metabolic Networks and Pathways
mitochondria
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - pathology
T cell
tumor metabolism
Tumor Microenvironment
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Summary:It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from resting tissues. More recently understood is that this metabolic phenotype is not unique to cancer cells but instead reflects characteristics of proliferating cells. Similar metabolic transitions also occur in the immune system as cells transition from resting state to stimulated effectors. A key finding in immune metabolism is that the metabolic programs of different cell subsets are distinctly associated with immunological function. Further, interruption of those metabolic pathways can shift immune cell fate to modulate immunity. These studies have identified numerous metabolic similarities between cancer and immune cells but also critical differences that may be exploited and that affect treatment of cancer and immunological diseases. Interest in metabolic interventions against malignancy, autoimmunity, and inflammation has surged with the recognition of shared metabolic features in cancer and immune cells. Andrejeva and Rathmell discuss the metabolic pathways that support cell proliferation and activity and contrast the metabolic challenges of cancer and immune cells in the tumor microenvironment.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2017.06.004