Primary central chondrosarcoma of long bone, limb girdle and trunk: Analysis of 174 cases by numerical scoring on histology

The aims of this study were: (i) to elucidate clinicopathological characteristics of pcCHS of long bones (L), limb girdles (LG) and trunk (T) in Japan; (ii) to investigate predictive pathological findings for outcome of pcCHS of L, LG and T, objectively; and (iii) to elucidate a discrepancy of grade...

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Bibliographic Details
Published in:Pathology international 2015-09, Vol.65 (9), p.468-475
Main Authors: Konishi, Eiichi, Nakashima, Yasuaki, Mano, Masayuki, Tomita, Yasuhiko, Nagasaki, Ikumitsu, Kubo, Toshikazu, Araki, Nobuhito, Haga, Hironori, Toguchida, Junya, Ueda, Takafumi, Sakuma, Toshiko, Imahori, Masaya, Morii, Eiichi, Yoshikawa, Hideki, Tsukamoto, Yoshitane, Futani, Hiroyuki, Wakasa, Kenichi, Hoshi, Manabu, Hamada, Shinshichi, Takeshita, Hideyuki, Inoue, Takeshi, Aono, Masanari, Kawabata, Kenji, Murata, Hiroaki, Katsura, Kanade, Urata, Yoji, Ueda, Hideki, Yanagisawa, Akio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bone Neoplasms - pathology
Chondrosarcoma - pathology
Female
Femur - pathology
grade
Histological Techniques
Humans
Humerus - pathology
Japan
Male
Middle Aged
Original
pathology
primary central chondrosarcoma
Prognosis
statistical analysis
Survival Rate
Young Adult
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Summary:The aims of this study were: (i) to elucidate clinicopathological characteristics of pcCHS of long bones (L), limb girdles (LG) and trunk (T) in Japan; (ii) to investigate predictive pathological findings for outcome of pcCHS of L, LG and T, objectively; and (iii) to elucidate a discrepancy of grade between biopsy and resected specimens. Clinicopathological profiles of 174 pcCHS (79 male, 95 female), of L, LG, and T were retrieved. For each case, a numerical score was given to 18 pathological findings. The average age was 50.5 years (15–80 years). Frequently involved sites were femur, humerus, pelvis and rib. The 5‐year and 10‐year disease‐specific survival (DSS) rates [follow‐up: 1–258 months (average 65.5)] were 87.0% and 80.4%, respectively. By Cox hazards analysis on pathological findings, age, sex and location, histologically higher grade and older age were unfavorable predictors, and calcification was a favorable predictor in DSS. The histological grade of resected specimen was higher than that of biopsy in 37.7% (26/69 cases). In conclusion, higher histological grade and older age were predictors for poor, but calcification was for good prognosis. Because there was a discrepancy in grade between biopsy and resected specimens, comprehensive evaluation is necessary before definitive operation for pcCHS.
ISSN:1320-5463
1440-1827
DOI:10.1111/pin.12324