More than the genes, the tumor microenvironment in neuroblastoma

Highlights • There is now evidence that the extracellualr matrix and normal cells in the tumor microenvironment of neuroblstoma tumors and metastases contribute to progression. • The communication between neuroblstoma cells and stromal cells is through a combination of adhesion-dependent and adhesio...

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Bibliographic Details
Published in:Cancer letters 2016-09, Vol.380 (1), p.304-314
Main Authors: Borriello, Lucia, Seeger, Robert C, Asgharzadeh, Shahab, DeClerck, Yves A
Format: Article
Language:English
Subjects:
Acids
Animals
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer
Cancer therapies
Cell Communication
Cell Movement
Cell Proliferation
Cell Survival
Cell–cell communication
Clinical trials
Colleges & universities
Consortia
Cytokines
Disease Progression
Gene Expression Regulation, Neoplastic
Genes
Growth factors
Hallmarks of cancer
Hematology, Oncology and Palliative Medicine
Humans
Immunotherapy
Kinases
Medical prognosis
Metastasis
Mutation
Neuroblastoma
Neuroblastoma - genetics
Neuroblastoma - metabolism
Neuroblastoma - pathology
Neuroblastoma - therapy
Pediatrics
Signal Transduction
Tumor Microenvironment
Tumors
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Summary:Highlights • There is now evidence that the extracellualr matrix and normal cells in the tumor microenvironment of neuroblstoma tumors and metastases contribute to progression. • The communication between neuroblstoma cells and stromal cells is through a combination of adhesion-dependent and adhesion-independent mechnnisms. • New therapies targeting these mechanims are now tested in multiple early phase clinical trials.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.11.017