A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior

A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg wi...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-07, Vol.53 (58), p.8156-8159
Main Authors: Jacob, NIcholas T, Anraku, Kensaku, Kimishima, Atsushi, Zhou, Bin, Collins, Karen C, Lockner, Jonathan W, Ellis, Beverley A, Janda, Kim D
Format: Article
Language:English
Subjects:
Animals
Antibodies - chemistry
Antibodies - immunology
Antibodies - pharmacology
Cocaine - antagonists & inhibitors
Cocaine - pharmacology
Disaccharides - antagonists & inhibitors
Disaccharides - immunology
Dose-Response Relationship, Drug
Locomotion - drug effects
Mice
Molecular Conformation
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Summary:A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg with superior efficacy compared to a standard conjugate.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc04055e