A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior

A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg wi...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-07, Vol.53 (58), p.8156-8159
Main Authors: Jacob, NIcholas T, Anraku, Kensaku, Kimishima, Atsushi, Zhou, Bin, Collins, Karen C, Lockner, Jonathan W, Ellis, Beverley A, Janda, Kim D
Format: Article
Language:English
Subjects:
Animals
Antibodies - chemistry
Antibodies - immunology
Antibodies - pharmacology
Cocaine - antagonists & inhibitors
Cocaine - pharmacology
Disaccharides - antagonists & inhibitors
Disaccharides - immunology
Dose-Response Relationship, Drug
Locomotion - drug effects
Mice
Molecular Conformation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c378t-72a0fe35a987f0c80cdf94dc0815c2bca6a8470acc8c17dd1a6f0d1ab66976a73
cites cdi_FETCH-LOGICAL-c378t-72a0fe35a987f0c80cdf94dc0815c2bca6a8470acc8c17dd1a6f0d1ab66976a73
container_end_page 8159
container_issue 58
container_start_page 8156
container_title Chemical communications (Cambridge, England)
container_volume 53
creator Jacob, NIcholas T
Anraku, Kensaku
Kimishima, Atsushi
Zhou, Bin
Collins, Karen C
Lockner, Jonathan W
Ellis, Beverley A
Janda, Kim D
description A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg with superior efficacy compared to a standard conjugate.
doi_str_mv 10.1039/c7cc04055e
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5559285</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1916380273</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-72a0fe35a987f0c80cdf94dc0815c2bca6a8470acc8c17dd1a6f0d1ab66976a73</originalsourceid><addsrcrecordid>eNpVkcFq3DAQhkVJaTbbXvIAwccQcCtZliVfAotJmkCgl5b2Jsbj8UbBK20ke0nevt4mWdI5zAzMxz_D_IydCv5VcFl_Q43IS64UfWALIasyV6X5c7TvVZ1rWapjdpLSA59DKPOJHRem0loLsWC_V1nrAgb_MK1hpGygHUVYO7_OnsiHSICj21EGfnRt6BylbAwZDDPn9jwGBOcpd76bkLqspXvYuRA_s489DIm-vNYl-3V99bO5ye9-fL9tVnc5Sm3GXBfAe5IKaqN7joZj19dlh9wIhUWLUIEpNQdEg0J3nYCq53Nuq6rWFWi5ZJcvutup3VCH5McIg91Gt4H4bAM4-__Eu3u7DjurlKoLo2aB81eBGB4nSqPduIQ0DOApTMmKWlTS8ELLGb14QTGGlCL1hzWC270TttFN88-Jqxk-e3_YAX17vfwL97iHGA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1916380273</pqid></control><display><type>article</type><title>A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior</title><source>Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)</source><creator>Jacob, NIcholas T ; Anraku, Kensaku ; Kimishima, Atsushi ; Zhou, Bin ; Collins, Karen C ; Lockner, Jonathan W ; Ellis, Beverley A ; Janda, Kim D</creator><creatorcontrib>Jacob, NIcholas T ; Anraku, Kensaku ; Kimishima, Atsushi ; Zhou, Bin ; Collins, Karen C ; Lockner, Jonathan W ; Ellis, Beverley A ; Janda, Kim D</creatorcontrib><description>A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg with superior efficacy compared to a standard conjugate.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c7cc04055e</identifier><identifier>PMID: 28677711</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Antibodies - chemistry ; Antibodies - immunology ; Antibodies - pharmacology ; Cocaine - antagonists &amp; inhibitors ; Cocaine - pharmacology ; Disaccharides - antagonists &amp; inhibitors ; Disaccharides - immunology ; Dose-Response Relationship, Drug ; Locomotion - drug effects ; Mice ; Molecular Conformation</subject><ispartof>Chemical communications (Cambridge, England), 2017-07, Vol.53 (58), p.8156-8159</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-72a0fe35a987f0c80cdf94dc0815c2bca6a8470acc8c17dd1a6f0d1ab66976a73</citedby><cites>FETCH-LOGICAL-c378t-72a0fe35a987f0c80cdf94dc0815c2bca6a8470acc8c17dd1a6f0d1ab66976a73</cites><orcidid>0000-0001-6759-4227</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28677711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacob, NIcholas T</creatorcontrib><creatorcontrib>Anraku, Kensaku</creatorcontrib><creatorcontrib>Kimishima, Atsushi</creatorcontrib><creatorcontrib>Zhou, Bin</creatorcontrib><creatorcontrib>Collins, Karen C</creatorcontrib><creatorcontrib>Lockner, Jonathan W</creatorcontrib><creatorcontrib>Ellis, Beverley A</creatorcontrib><creatorcontrib>Janda, Kim D</creatorcontrib><title>A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg with superior efficacy compared to a standard conjugate.</description><subject>Animals</subject><subject>Antibodies - chemistry</subject><subject>Antibodies - immunology</subject><subject>Antibodies - pharmacology</subject><subject>Cocaine - antagonists &amp; inhibitors</subject><subject>Cocaine - pharmacology</subject><subject>Disaccharides - antagonists &amp; inhibitors</subject><subject>Disaccharides - immunology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Locomotion - drug effects</subject><subject>Mice</subject><subject>Molecular Conformation</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkcFq3DAQhkVJaTbbXvIAwccQcCtZliVfAotJmkCgl5b2Jsbj8UbBK20ke0nevt4mWdI5zAzMxz_D_IydCv5VcFl_Q43IS64UfWALIasyV6X5c7TvVZ1rWapjdpLSA59DKPOJHRem0loLsWC_V1nrAgb_MK1hpGygHUVYO7_OnsiHSICj21EGfnRt6BylbAwZDDPn9jwGBOcpd76bkLqspXvYuRA_s489DIm-vNYl-3V99bO5ye9-fL9tVnc5Sm3GXBfAe5IKaqN7joZj19dlh9wIhUWLUIEpNQdEg0J3nYCq53Nuq6rWFWi5ZJcvutup3VCH5McIg91Gt4H4bAM4-__Eu3u7DjurlKoLo2aB81eBGB4nSqPduIQ0DOApTMmKWlTS8ELLGb14QTGGlCL1hzWC270TttFN88-Jqxk-e3_YAX17vfwL97iHGA</recordid><startdate>20170718</startdate><enddate>20170718</enddate><creator>Jacob, NIcholas T</creator><creator>Anraku, Kensaku</creator><creator>Kimishima, Atsushi</creator><creator>Zhou, Bin</creator><creator>Collins, Karen C</creator><creator>Lockner, Jonathan W</creator><creator>Ellis, Beverley A</creator><creator>Janda, Kim D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6759-4227</orcidid></search><sort><creationdate>20170718</creationdate><title>A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior</title><author>Jacob, NIcholas T ; Anraku, Kensaku ; Kimishima, Atsushi ; Zhou, Bin ; Collins, Karen C ; Lockner, Jonathan W ; Ellis, Beverley A ; Janda, Kim D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-72a0fe35a987f0c80cdf94dc0815c2bca6a8470acc8c17dd1a6f0d1ab66976a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antibodies - chemistry</topic><topic>Antibodies - immunology</topic><topic>Antibodies - pharmacology</topic><topic>Cocaine - antagonists &amp; inhibitors</topic><topic>Cocaine - pharmacology</topic><topic>Disaccharides - antagonists &amp; inhibitors</topic><topic>Disaccharides - immunology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Locomotion - drug effects</topic><topic>Mice</topic><topic>Molecular Conformation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacob, NIcholas T</creatorcontrib><creatorcontrib>Anraku, Kensaku</creatorcontrib><creatorcontrib>Kimishima, Atsushi</creatorcontrib><creatorcontrib>Zhou, Bin</creatorcontrib><creatorcontrib>Collins, Karen C</creatorcontrib><creatorcontrib>Lockner, Jonathan W</creatorcontrib><creatorcontrib>Ellis, Beverley A</creatorcontrib><creatorcontrib>Janda, Kim D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacob, NIcholas T</au><au>Anraku, Kensaku</au><au>Kimishima, Atsushi</au><au>Zhou, Bin</au><au>Collins, Karen C</au><au>Lockner, Jonathan W</au><au>Ellis, Beverley A</au><au>Janda, Kim D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2017-07-18</date><risdate>2017</risdate><volume>53</volume><issue>58</issue><spage>8156</spage><epage>8159</epage><pages>8156-8159</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg with superior efficacy compared to a standard conjugate.</abstract><cop>England</cop><pmid>28677711</pmid><doi>10.1039/c7cc04055e</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6759-4227</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1359-7345
ispartof Chemical communications (Cambridge, England), 2017-07, Vol.53 (58), p.8156-8159
issn 1359-7345
1364-548X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5559285
source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Animals
Antibodies - chemistry
Antibodies - immunology
Antibodies - pharmacology
Cocaine - antagonists & inhibitors
Cocaine - pharmacology
Disaccharides - antagonists & inhibitors
Disaccharides - immunology
Dose-Response Relationship, Drug
Locomotion - drug effects
Mice
Molecular Conformation
title A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T08%3A18%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20bioconjugate%20leveraging%20xenoreactive%20antibodies%20to%20alleviate%20cocaine-induced%20behavior&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Jacob,%20NIcholas%20T&rft.date=2017-07-18&rft.volume=53&rft.issue=58&rft.spage=8156&rft.epage=8159&rft.pages=8156-8159&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c7cc04055e&rft_dat=%3Cproquest_pubme%3E1916380273%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c378t-72a0fe35a987f0c80cdf94dc0815c2bca6a8470acc8c17dd1a6f0d1ab66976a73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1916380273&rft_id=info:pmid/28677711&rfr_iscdi=true