Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats

• Published in: Neuroscience bulletin 2013-06, Vol.29 (3), p.287-294
• Main Authors: Li, Xinjuan, Han, Hua, Hou, Ruanling, Wei, Linyu, Wang, Guohong, Li, Chaokun, Li, Dongliang
• Format: Article
• Language: English
• Subjects: Anatomy; Anesthesiology; Animals; Animals, Newborn; Biomedical and Life Sciences; Biomedicine; Female; Glucose - metabolism; Glucose Transporter Type 1 - drug effects; Glucose Transporter Type 1 - metabolism; Glucose Transporter Type 3 - drug effects; Glucose Transporter Type 3 - metabolism; Hippocampus - drug effects; Hippocampus - metabolism; Human Physiology; Hypoxia - metabolism; Neurology; Neurons - drug effects; Neurons - metabolism; Neurosciences; Original; Original Article; Pain Medicine; Pregnancy; Progesterone - pharmacology; Rats; Rats, Sprague-Dawley; Reperfusion Injury - drug therapy; 创伤性脑损伤; 实验; 新生大鼠; 海马神经元; 激素治疗; 神经保护作用; 缺氧缺血; 葡萄糖转运蛋白
• ISSN: 1673-7067; 1995-8218
• DOI: 10.1007/s12264-013-1298-y

Progesterone is an efficient candidate for treating stroke and traumatic brain damage. The current study was designed to investigate the effects of pro gesterone on glucose transporter proteins （GLUT1 and GLUT3） during hypoxicischemic injury in a neo natal rat model. We demonstrated strong staining for GLUT1 in the walls of blood vessels and GLUT3 im munoreactivity in hippocampal neurons after hypoxia ischemia. Hypoxiaischemia elevated GLUT1 and GLUT3 at both the mRNA and protein levels in the hippocampus, and pretreatment with progesterone （8 mg/kg） further enhanced their accumulation until 24 h after hypoxicischemic injury. These results showed that progesterone treatment induced the accumula tion of both GLUT1 and GLUT3 transporters, and an energycompensation mechanism may be involved in the neuroprotective effect of progesterone during hy poxicischemic injury after cerebral ischemic attacks.