An Overview of Genome-Wide Association Studies in Alzheimer’s Disease

Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer’s disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk geneti...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience bulletin 2016-04, Vol.32 (2), p.183-190
Main Authors: Shen, Luxi, Jia, Jianping
Format: Article
Language:English
Subjects:
Advertising executives
Alzheimer Disease - genetics
Alzheimer's disease
Anatomy
Anesthesiology
Apolipoprotein E4 - genetics
Apolipoproteins
Biomedical and Life Sciences
Biomedicine
Disease susceptibility
Genetic Predisposition to Disease - genetics
Genetic research
Genome-Wide Association Study
Genomics
Human Physiology
Humans
Medical research
Medicine, Experimental
Neurology
Neurosciences
Pain Medicine
Review
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer’s disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-016-0011-3