Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum-Sensitive, Platinum-Resistant, and Platinum-Refractory Epithelial Ovarian Cancer

Diverse proinflammatory biomarkers and oxidative stress are strongly associated with advanced epithelial ovarian cancer (EOC). Objective. To determine the behavior of markers of oxidative stress and inflammation in plasma and ascites fluid in patients with platinum-sensitive, platinum-resistant, and...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2017, Vol.2017 (2017), p.1-8
Main Authors: Rodríguez-Carrizalez, Adolfo Daniel, Sifuentes-Franco, Sonia, Carrillo-Ibarra, Sandra, Bañuelos-Ramírez, Jose Luis, Miranda-Díaz, Alejandra Guillermina, Cantón-Romero, Juan Carlos, José Alberto, Castellanos-González
Format: Article
Language:English
Subjects:
Adult
Aged
Antioxidants - metabolism
Ascites - blood
Biomarkers
Biomarkers, Tumor - metabolism
Cancer therapies
Carcinoma, Ovarian Epithelial
Care and treatment
Chemotherapy
Diagnosis
Drug Resistance, Neoplasm - drug effects
Female
Gynecology
Health aspects
Hospitals
Humans
Immunity
Inflammation
Inflammation - blood
Inflammation - pathology
Interleukin-6 - blood
Isoprostanes - blood
Lipid Peroxides - blood
Medical prognosis
Medical research
Metastasis
Middle Aged
Neoplasms, Glandular and Epithelial - blood
Neoplasms, Glandular and Epithelial - drug therapy
Neoplasms, Glandular and Epithelial - pathology
Obstetrics
Oncology
Ovarian cancer
Ovarian Neoplasms - blood
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - pathology
Oxidative stress
Oxidative Stress - drug effects
Plasma
Platinum - pharmacology
Platinum - therapeutic use
Tumor Necrosis Factor-alpha - blood
Tumor necrosis factor-TNF
Tumors
Vascular endothelial growth factor
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Summary:Diverse proinflammatory biomarkers and oxidative stress are strongly associated with advanced epithelial ovarian cancer (EOC). Objective. To determine the behavior of markers of oxidative stress and inflammation in plasma and ascites fluid in patients with platinum-sensitive, platinum-resistant, and platinum-refractory EOC. Methods. A prospective cohort study. The colorimetric method was used to determine levels of the markers 8-isoprostanes (8-IP), lipid peroxidation products (LPO), and total antioxidant capacity (TAC) in plasma and ascites fluid; and with ELISA, the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) were determined in patients with EOC. Results. In ascites fluid, a significant increase in 8-IP versus baseline plasma levels was found (p=0.002). There was an important leakage of the TAC levels in ascites fluid versus baseline plasma levels (p
ISSN:1942-0900
1942-0994
DOI:10.1155/2017/2873030