Association between genetic variants and esophageal cancer risk

We investigated whether single nucleotide polymorphisms (SNPs) in the nuclear assembly factor 1 (NAF1) and TNFAIP3-interacting protein 1 (TNIP1) gene were associated with susceptibility to esophageal cancer in a Chinese Han population. Five SNPs were genotyped and their relationship with esophageal...

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Bibliographic Details
Published in:Oncotarget 2017-07, Vol.8 (29), p.47167-47174
Main Authors: Yue, Chenli, Li, Miao, Da, Chenxing, Meng, Hongtao, Lv, Shaomin, Zhao, Xinhan
Format: Article
Language:English
Subjects:
Aged
Alleles
Asian Continental Ancestry Group - genetics
Biomarkers, Tumor
Case-Control Studies
China
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Variation
Genotype
Haplotypes
Humans
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Research Paper
Ribonucleoproteins - genetics
Risk
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Summary:We investigated whether single nucleotide polymorphisms (SNPs) in the nuclear assembly factor 1 (NAF1) and TNFAIP3-interacting protein 1 (TNIP1) gene were associated with susceptibility to esophageal cancer in a Chinese Han population. Five SNPs were genotyped and their relationship with esophageal cancer risk was analyzed in a sample of 386 esophageal cancer patients and 495 unrelated healthy controls recruited from the First Affiliated Hospital of Xi'an Jiaotong University. Patients with the AG genotype of rs2320615 were at lower risk of developing esophageal cancer than those with the GG genotype (adjusted odds ratio [OR] = 0.64, 95% confidence interval [CI] = 0.46-0.90, P = 0.009). The rs2320615 SNP was found to be associated with a decreased the risk of esophageal cancer in the dominant model (adjusted OR = 0.70, 95% CI = 0.51-0.96, P = 0.026). These results provide the first evidence that the rs2320615 in NAF1 was associated with reduced risk of esophageal cancer. Further studies with larger samples are warranted to confirm our findings.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.17006