ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE)

Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity...

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Published in:African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2016-01, Vol.13 (4), p.162-165
Main Authors: Roca-Mézquita, Carolina, Graniel-Sabido, Manlio, Moo-Puc, Rosa E, Leon-Déniz, Lorena V, Gamboa-León, Rubí, Arjona-Ruiz, Carely, Tun-Garrido, Juan, Mirón-López, Gumersindo, Mena- Rejón, Gonzalo J
Format: Article
Language:English
Subjects:
antiprotozoal activity
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - pharmacology
Celastraceae
Celastraceae - chemistry
Elaeodendron trichotomum
Entamoeba histolytica - drug effects
Giardia lamblia - drug effects
Mexico
Parasitic Sensitivity Tests
Plant Bark - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Leaves - chemistry
Plant Roots - chemistry
pristimerin
root bark
tingenone
Trypanosoma cruzi - drug effects
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Summary:Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum , a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases. Materials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested against Entamoeba histolytica , Giardia lamblia , Trichomonas vaginalis , and Trypanosoma cruzi . A quantitative HPLC analysis of pristimerin and tingenone was performed. Results: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50's of 0.80, 0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%). Conclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa.
ISSN:0189-6016
2505-0044
DOI:10.21010/ajtcam.v13i4.21