Clinical Predictors for Neutrophil-to-Lymphocyte Ratio Changes in Patients with Chronic Hepatitis B Receiving Peginterferon Treatment

A lower neutrophil-to-lymphocyte ratio (NLR) was found to be associated with better clinical outcomes in hepatitis B-related liver cirrhosis and hepatocellular carcinoma. We aimed to identify pre-therapeutic variables capable of predicting NLR changes in patients with hepatitis B receiving peginterf...

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Bibliographic Details
Published in:In vivo (Athens) 2017-07, Vol.31 (4), p.723-729
Main Authors: Le, Puo-Hsien, Liang, Kung-Hao, Chang, Ming-Ling, Hsu, Chao-Wei, Chen, Yi-Cheng, Lin, Chih-Lang, Lin, Wey-Ran, Lai, Ming-Wei, Yeh, Chau-Ting
Format: Article
Language:English
Subjects:
Adult
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - virology
Female
Hemoglobins - isolation & purification
Hepatitis B Surface Antigens - isolation & purification
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - drug therapy
Hepatitis B, Chronic - virology
Humans
Interferon-alpha - administration & dosage
Interferon-alpha - adverse effects
Liver Neoplasms - blood
Liver Neoplasms - drug therapy
Liver Neoplasms - pathology
Lymphocyte Count
Lymphocytes - drug effects
Lymphocytes - pathology
Male
Middle Aged
Neutrophils - drug effects
Neutrophils - pathology
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - adverse effects
Recombinant Proteins - administration & dosage
Recombinant Proteins - adverse effects
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Summary:A lower neutrophil-to-lymphocyte ratio (NLR) was found to be associated with better clinical outcomes in hepatitis B-related liver cirrhosis and hepatocellular carcinoma. We aimed to identify pre-therapeutic variables capable of predicting NLR changes in patients with hepatitis B receiving peginterferon therapy. The baseline clinicopathological data were analyzed to correlate with NLR changes before and 1 year after peginterferon treatment in 71 patients with hepatitis B. Univariate analysis revealed that pre-treatment NLR itself negatively predicted NLR changes following peginterferon treatment (odds ratio(OR)=0.320, p=0.013). Further analysis identified pre-treatment NLR, hemoglobin and hepatitis B surface antigen level as independent predictors for NLR changes (adjusted p=0.028, 0.005, and 0.028, respectively). A predictive score composed of these three factors had an area under the curve of 76.5% (p
ISSN:1791-7549
0258-851X
1791-7549
DOI:10.21873/invivo.11121