Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure

Background The majority of individuals with post-traumatic headache have symptoms that are indistinguishable from migraine. The overlap in symptoms amongst these individuals raises the question as to whether post-traumatic headache has a unique pathophysiology or if head trauma triggers migraine. Th...

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Bibliographic Details
Published in:Journal of headache and pain 2017-08, Vol.18 (1), p.87-87, Article 87
Main Authors: Schwedt, Todd J., Chong, Catherine D., Peplinski, Jacob, Ross, Katherine, Berisha, Visar
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Anatomy & physiology
Brain - diagnostic imaging
Brain - pathology
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - pathology
Case-Control Studies
Cortex (parietal)
Female
Frontal lobe
Functional anatomy
Headache
Headaches
Humans
Internal Medicine
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Migraine
Migraine Disorders - diagnostic imaging
Migraine Disorders - pathology
Neuroimaging
Neurology
NMR
Nuclear magnetic resonance
Pain Medicine
Post traumatic stress disorder
Post-Traumatic Headache - diagnostic imaging
Post-Traumatic Headache - pathology
Research Article
Structure-function relationships
Surface area
Traumatic brain injury
Young Adult
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Summary:Background The majority of individuals with post-traumatic headache have symptoms that are indistinguishable from migraine. The overlap in symptoms amongst these individuals raises the question as to whether post-traumatic headache has a unique pathophysiology or if head trauma triggers migraine. The objective of this study was to compare brain structure in individuals with persistent post-traumatic headache (i.e. headache lasting at least 3 months following a traumatic brain injury) attributed to mild traumatic brain injury to that of individuals with migraine. Methods Twenty-eight individuals with persistent post-traumatic headache attributed to mild traumatic brain injury and 28 individuals with migraine underwent brain magnetic resonance imaging on a 3 T scanner. Regional volumes, cortical thickness, surface area and curvature measurements were calculated from T1-weighted sequences and compared between subject groups using ANCOVA. MRI data from 28 healthy control subjects were used to interpret the differences in brain structure between migraine and persistent post-traumatic headache. Results Differences in regional volumes, cortical thickness, surface area and brain curvature were identified when comparing the group of individuals with persistent post-traumatic headache to the group with migraine. Structure was different between groups for regions within the right lateral orbitofrontal lobe, left caudal middle frontal lobe, left superior frontal lobe, left precuneus and right supramarginal gyrus ( p  
ISSN:1129-2369
1129-2377
DOI:10.1186/s10194-017-0796-0