Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-14
Main Authors: Paragh, Lilla, Törőcsik, Daniel
Format: Article
Language:English
Subjects:
Arthritis
Blood coagulation factors
Blood platelets
Bone marrow
Coagulation factors
Coronary vessels
Dermatology
Dermis
Diagnosis
Diagnostic systems
Enzymes
Factor XIII - genetics
Factor XIII - isolation & purification
Fibroblasts
Health aspects
Hemostasis
Hemostasis - genetics
Hemostatics
Homeostasis
Humans
Inflammation - diagnosis
Inflammation - genetics
Inflammation - pathology
Inflammation - therapy
Leg ulcers
Pathogenesis
Physiological aspects
Plasma
Review
Skin
Skin - metabolism
Skin - pathology
Skin diseases
Skin Diseases - diagnosis
Skin Diseases - metabolism
Skin Diseases - pathology
Skin Diseases - therapy
Vascular surgery
Wound healing
Wound Healing - genetics
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Summary:The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin. We summarize the intracellular functions of FXIII-A as well as its possible sources in the extracellular space of the dermis with a focus on its relevance to skin homeostasis and disease pathogenesis. Finally, the potential role of FXIII-A in wound healing, as a field with long-term therapeutic implications, is also discussed.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/3571861