Direct Assessment of Wall Shear Stress by Signal Intensity Gradient from Time-of-Flight Magnetic Resonance Angiography

• Published in: BioMed research international 2017-01, Vol.2017 (2017), p.1-8
• Main Authors: Jeong, Seul-Ki, Chung, Gyung-Ho, Park, Se-Hyoung, Ryu, Han Uk, Lee, Sang Hyuk, Han, Kap-Soo, Cho, Young I.
• Format: Article
• Language: English
• Subjects: Analysis; Angiography; Blood circulation disorders; Blood flow; Blood vessels; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - diagnostic imaging; Cardiovascular Diseases - physiopathology; Care and treatment; Carotid Arteries; Carotid artery; Carotid Artery, Common - diagnostic imaging; Carotid Artery, Common - physiopathology; Carotid Stenosis - diagnosis; Carotid Stenosis - diagnostic imaging; Carotid Stenosis - physiopathology; Computational fluid dynamics; Computer applications; Contrast Media - therapeutic use; Correlation coefficient; Correlation coefficients; Flow velocity; Fluid dynamics; Health risks; Humans; Hydrodynamics; Magnetic resonance; Magnetic Resonance Angiography - methods; Magnetic Resonance Imaging - methods; Mathematical analysis; Mechanical stimuli; NMR; Nuclear magnetic resonance; Shear (Mechanics); Shear stress; Veins & arteries
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2017/7087086

The aim of the study was to calculate the arterial wall signal intensity gradient (SIG) from time-of-flight MR angiography (TOF-MRA) and represent arterial wall shear stress. We developed a new algorithm that uses signal intensity (SI) of a TOF-MRA to directly calculate the signal intensity gradient (SIG). The results from our phantom study showed that the TOF-MRA SIG could be used to distinguish the magnitude of blood flow rate as high (mean SIG ± SD, 2.2 ± 0.4 SI/mm for 12.5 ± 2.3 L/min) and low (0.9 ± 0.3 SI/mm for 8.5 ± 2.6 L/min) in vessels (p