Meeting the WHO 90% target: antiretroviral treatment efficacy in Poland is associated with baseline clinical patient characteristics

Introduction: Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV‐1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral treatment efficacy in Poland and to identify variab...

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Published in:Journal of the International AIDS Society 2017-07, Vol.20 (1), p.21847-n/a
Main Authors: Parczewski, Milosz, Siwak, Ewa, Leszczyszyn‐Pynka, Magdalena, Cielniak, Iwona, Burkacka, Ewa, Pulik, Piotr, Witor, Adam, Muller, Karolina, Zasik, Ewelina, Grzeszczuk, Anna, Jankowska, Maria, Lemańska, Małgorzata, Olczak, Anita, Grąbczewska, Edyta, Szymczak, Aleksandra, Gąsiorowski, Jacek, Szetela, Bartosz, Bociąga‐Jasik, Monika, Skwara, Paweł, Witak‐Jędra, Magdalena, Jabłonowska, Elżbieta, Wójcik‐Cichy, Kamila, Kamerys, Juliusz, Janczarek, Małgorzata, Krankowska, Dagny, Mikuła, Tomasz, Kozieł, Katarzyna, Bielec, Dariusz, Stempkowska, Justyna, Kocbach, Aleksandra, Błudzin, Wiesława, Horban, Andrzej
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
Age Factors
AIDS
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
antiretroviral treatment
Care and treatment
cART efficacy
CD4 Lymphocyte Count
Cross-Sectional Studies
Dosage and administration
Drug resistance
Drug Therapy, Combination
Female
Health Planning
Hepatitis C virus
HIV
HIV Infections - drug therapy
HIV-1
Human immunodeficiency virus
Humans
Load distribution
Lymphocytes
Male
Middle Aged
Patient outcomes
Poland
Teenagers
Treatment Outcome
Viral Load
viral replication
virologic control
virologic suppression
WHO target
World Health Organization
Young Adult
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Summary:Introduction: Modern combined antiretroviral therapies (cART) allow to effectively suppress HIV‐1 viral load, with the 90% virologic success rate, meeting the WHO target in most clinical settings. The aim of this study was to analyse antiretroviral treatment efficacy in Poland and to identify variables associated with virologic suppression. Methods: Cross‐sectional data on 5152 (56.92% of the countrywide treated at the time‐point of analysis) patients on cART for more than six months with at least one HIV‐RNA measurement in 2016 were collected from 14 Polish centres. Patients’ characteristics and treatment type‐based outcomes were analysed for the virologic suppression thresholds of
ISSN:1758-2652
1758-2652
DOI:10.7448/IAS.20.1.21847