A promising azeotrope-like mosquito repellent blend

Topical repellents play a key role in reducing the outdoor transmission of mosquito-borne diseases by reducing human-vector contact. Excellent repellents are available, but there is always room for improvement. This article reports on a particularly effective binary repellent blend of ethyl butylace...

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Bibliographic Details
Published in:Scientific reports 2017-08, Vol.7 (1), p.10273-10273, Article 10273
Main Authors: Izadi, Homa, Focke, Walter W, Asaadi, Erfan, Maharaj, Rajendra, Pretorius, Jannie, Loots, Mattheüs Theodor
Format: Article
Language:English
Subjects:
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Aquatic insects
DEET
Disease transmission
Evaporation
Humanities and Social Sciences
Medical research
Mosquitoes
multidisciplinary
Repellents
Science
Science (multidisciplinary)
Vapor pressure
Vector-borne diseases
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Summary:Topical repellents play a key role in reducing the outdoor transmission of mosquito-borne diseases by reducing human-vector contact. Excellent repellents are available, but there is always room for improvement. This article reports on a particularly effective binary repellent blend of ethyl butylacetylaminopropionate and nonanoic acid. A composition containing 25 mol% of the acid exhibits negative pseudo-azeotrope behaviour at 50 °C, meaning that the liquid vapour pressure is lower than that of the parent compounds and evaporation occurs without a change in the liquid composition. In tests performed using the South African Medical Research Council’s cup-on-arm procedure, this mixture provided better protection for a longer time than the “gold standard of mosquito repellents”, namely N,N-diethyl-m-toluamide, commonly known as DEET.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-10548-y