Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia–ischemia

Highlights • Sex differences in mitochondrial quality control may contribute to the relative male vulnerability to HI. • Mitochondrial fission occurs, to differing degrees, in both sexes after hypoxia–ischemia (HI) injury. • Constitutive autophagy is higher in male brain than female brain at postnat...

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Bibliographic Details
Published in:Neuroscience 2016-10, Vol.335, p.103-113
Main Authors: Demarest, T.G, Waite, E.L, Kristian, T, Puche, A.C, Waddell, J, McKenna, M.C, Fiskum, G
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Brain - physiopathology
cell death
Disease Models, Animal
Female
Hypoxia-Ischemia, Brain - physiopathology
lysosome
Male
Mitochondria
Mitochondrial Degradation - physiology
mitophagy
morphology
Neurology
Neurons
Rats, Sprague-Dawley
sex-dependent
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Summary:Highlights • Sex differences in mitochondrial quality control may contribute to the relative male vulnerability to HI. • Mitochondrial fission occurs, to differing degrees, in both sexes after hypoxia–ischemia (HI) injury. • Constitutive autophagy is higher in male brain than female brain at postnatal day 8 in rats. • Mitophagy is increased in the cortex of female, but not male brain after HI injury. • Neuronal death occurs bilaterally in male brain and unilaterally in female brain.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.08.026