Lack of association between urotensin-II (UTS2) gene polymorphisms (Thr21Met and Ser89Asn) and migraine

Migraine is a common neurovascular brain disorder with heterogeneous clinical presentation, including recurrent headache attacks. The pathophysiology of migraine is complex, and a number of genomic regions have been associated with the development of migraine. In this study, we analyzed the allele a...

Full description

Saved in:
Bibliographic Details
Published in:Bosnian journal of basic medical sciences 2017-08, Vol.17 (3), p.268-273
Main Authors: Ozan, Betül, Demiryürek, Seniz, Safdar, Muhammad, Inanc, Yusuf, Demiryürek, Abdullah Tuncay
Format: Article
Language:English
Subjects:
Adult
Alleles
Amino Acid Substitution
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Migraine Disorders - epidemiology
Migraine Disorders - genetics
Migraine with Aura - epidemiology
Migraine with Aura - genetics
Migraine without Aura - epidemiology
Migraine without Aura - genetics
Polymorphism, Genetic - genetics
Polymorphism, Restriction Fragment Length
Risk Assessment
Turkey - epidemiology
Urotensins - genetics
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Migraine is a common neurovascular brain disorder with heterogeneous clinical presentation, including recurrent headache attacks. The pathophysiology of migraine is complex, and a number of genomic regions have been associated with the development of migraine. In this study, we analyzed the allele and genotype frequencies of the urotensin-II gene (UTS2) polymorphisms, Thr21Met and Ser89Asn, among Turkish patients with migraine. A total of 146 patients with migraine (14 with aura [MA group] and 132 without aura [MO group]) were genotyped for Thr21Met and Ser89Asn polymorphisms and compared with 154 age- and sex-matched healthy controls. The UTS2 gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). No significant differences were observed in allele and genotype frequencies for Thr21Met and Ser89Asn polymorphisms between the patients with migraine and control group. Similarly, we did not observe significant differences in allele and genotype frequencies between MA and MO and control group. Moreover, the haplotype analysis showed no association between UTS2 gene haplotypes (MN, MS, TN, and TS) and migraine. In summary, Thr21Met and Ser89Asn polymorphisms of the UTS2 gene are not risk factors for migraine in our sample of Turkish migraine patients.
ISSN:1512-8601
1840-4812
DOI:10.17305/bjbms.2017.2138