Novel synthetic adhesive as an effective alternative to Fibrin based adhesives

• Published in: World journal of hepatology 2017-08, Vol.9 (24), p.1030-1039
• Main Authors: Srinivasan, Pramod Kadaba, Sperber, Vera, Afify, Mamdouh, Tanaka, Hirokazu, Fukushima, Kenji, Kögel, Babette, Gremse, Felix, Tolba, René
• Format: Article
• Language: English
• Subjects: Basic Study
• ISSN: 1948-5182; 1948-5182
• DOI: 10.4254/wjh.v9.i24.1030

AIM To compare a novel, fully synthetic, polyurethane based glue(MAR-1) to fibrin sealant in a partial liver resection rat model.METHODS After 50% resection of the lateral left liver lobe in male Wistar rats(n = 7/group/time point), MAR-1, Fibrin or Na Cl was applied. After 14, 21 and 90 postoperative days, sealant degradation, intra-abdominal adhesions were scored, and histological examination of liver tissue was performed.RESULTS(Mean ± SEM)(MAR-1 vs Fibrin vs Na Cl). Bleeding mass was significantly higher in Na Cl(3.36 ± 0.51 g)compared to MAR-1(1.44 ± 0.40 g) and Fibrin(1.16 ± 0.32 g). At 14 and 90 d, bleeding time was significantly lower in MAR-1(6.00 ± 0.9 s; 13.57 ± 3.22 s) and Fibrin(3.00 ± 0.44 s; 22.2 ± 9.75 s) compared to Na Cl(158.16 ± 11.36 s; 127.5 ± 23.3 s). ALT levels were significantly higher in MAR-1(27.66 ± 1 U/L) compared to Fibrin(24.16 ± 0.98 U/L) and Na Cl(23.85 ± 0.80 U/L). Intrabdominal adhesions were significantly lower in MAR-1(11.22% ± 5.5%) compared to Na Cl(58.57% ± 11.83%). Degradation of the glue was observed and MAR-1 showed almost no traces of glue in the abdominal cavity as compared to the Fibrin(10% ± 5% 14 d; 7% ± 3% 21 d). Survival showed no significant differences between the groups.CONCLUSION Compared to Fibrin, MAR-1 showed similar hemostatic properties, no adverse effects, and is biocompatible. Further studies on adhesion strength and biodegradability of synthetic sealants are warranted.