Troy is expressed in human stomach mucosa and a novel putative prognostic marker of intestinal type gastric cancer

Epithelial stem cells of gastrointestinal tissues are characterized and controlled by an active Wnt signaling. Recently, the Wnt target gene has been proposed as a neoplastic marker in the murine intestine. In this study, we explored the putative tumor biological significance of Troy in humans by us...

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Published in:Oncotarget 2017-08, Vol.8 (31), p.50557-50569
Main Authors: Wilhelm, Franziska, Böger, Christine, Krüger, Sandra, Behrens, Hans-Michael, Röcken, Christoph
Format: Article
Language:English
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Research Paper
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Summary:Epithelial stem cells of gastrointestinal tissues are characterized and controlled by an active Wnt signaling. Recently, the Wnt target gene has been proposed as a neoplastic marker in the murine intestine. In this study, we explored the putative tumor biological significance of Troy in humans by using immunohistochemistry (104 cases), quantitative RT-PCR (50 cases) and cell culture experiments (MKN45, MKN74). In the non-neoplastic gastric mucosa, Troy was expressed by Muc5AC-positive foveolar epithelium, parietal cells, chief cells and cells of the intestinal metaplasia. In gastric cancer, Troy was found in the desmoplastic stroma and tumor cells. The overall staining intensity of the tumor cells was lower compared with the adjacent non-neoplastic mucosa, Troy was found significantly more commonly in intestinal compared with diffuse type gastric cancer (p=0.001) and correlated inversely with tumor grade (p
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.10672