A Novel Genetic Group of Bovine Hepacivirus in Archival Serum Samples from Brazilian Cattle

Hepatitis C virus (HCV) (genus Hepacivirus; family Flaviviridae) is a major human pathogen causing persistent infection and hepatic injury. Recently, emerging HCV-like viruses were described infecting wild animals, such as bats and rodents, and domestic animals, including dogs, horses, and cattle. U...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017, p.4732520-4
Main Authors: Canal, Cláudio W., Weber, Matheus N., Cibulski, Samuel P., Silva, Mariana S., Puhl, Daniela E., Stalder, Hanspeter, Peterhans, Ernst
Format: Article
Language:English
Subjects:
Animals
Bats
Bayesian analysis
Bioinformatics
Biological products
Brazil
Cattle
Cell culture
Diseases
Dogs
Domestic animals
Genetic aspects
Genetic Variation
Genome, Viral
Health aspects
Hepacivirus - genetics
Hepacivirus - pathogenicity
Hepatitis
Hepatitis C
Hepatitis C - blood
Hepatitis C - genetics
Hepatitis C - veterinary
Hepatitis C - virology
Horses
Humans
Markov analysis
Phylogenetics
Phylogeny
Primers
Rodents
Studies
Virology
Viruses
Wild animals
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Summary:Hepatitis C virus (HCV) (genus Hepacivirus; family Flaviviridae) is a major human pathogen causing persistent infection and hepatic injury. Recently, emerging HCV-like viruses were described infecting wild animals, such as bats and rodents, and domestic animals, including dogs, horses, and cattle. Using degenerate primers for detecting bovine pestiviruses in a 1996 survey three bovine serum samples showed a low identity with the genus Pestivirus of the Flaviviridae family. A virus could not be isolated in cell culture. The description of bovine hepaciviruses (BovHepV) in 2015 allowed us to retrospectively identify the sequences as BovHepV, with a 88.9% nucleotide identity. In a reconstructed phylogenetic tree, the Brazilian BovHepV samples grouped within the bovine HCV-like cluster in a separated terminal node that was more closely related to the putative bovine Hepacivirus common ancestor than to bovine hepaciviruses detected in Europe and Africa.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/4732520