Inhibitory effects of low-intensity pulsed ultrasound sonication on the proliferation of osteosarcoma cells

To date, there is limited data on the biological effects of low-intensity pulsed ultrasound (LIPUS) on primary malignant bone tumors. The purpose of the present study was to investigate the antitumor effects of LIPUS on osteosarcoma cells. The effects of LIPUS on cell viability, induction of apoptos...

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Bibliographic Details
Published in:Oncology letters 2017-09, Vol.14 (3), p.3071-3076
Main Authors: Matsuo, Toshihiro, Sato, Keiji, Matsui, Takuya, Sawada, Shigeyuki, Muramatsu, Yoshitaka, Kawanami, Katsuhisa, Deie, Masataka
Format: Article
Language:English
Subjects:
Apoptosis
Bone cancer
Care and treatment
Cell growth
Chemotherapy
Development and progression
Flow cytometry
Fractures
Laboratories
LM8
low-intensity pulsed ultrasound
Medical prognosis
Medical ultrasonics
Oncology
Osteosarcoma
Patient outcomes
Proteins
Sarcoma
sonication
Ultrasonic imaging
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Summary:To date, there is limited data on the biological effects of low-intensity pulsed ultrasound (LIPUS) on primary malignant bone tumors. The purpose of the present study was to investigate the antitumor effects of LIPUS on osteosarcoma cells. The effects of LIPUS on cell viability, induction of apoptosis, mitochondrial membrane potential and intracellular signaling molecules in the LM8 osteosarcoma cell line were investigated. LIPUS inhibited cell viability (P=0.0022) and mitochondrial membrane potential (P=0.0019) in LM8 cells. Flow cytometry analysis and terminal deoxynucleotidyl transferase dUTP nick end labeling staining revealed significantly higher numbers of apoptotic (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.6472