Immune Complex Membranoproliferative Glomerulonephritis Associated with Transjugular Intrahepatic Portosystemic Shunts in Alcoholic Cirrhosis: Two Case Reports

Objective: To report on 2 patients with alcoholic cirrhosis who were treated with transjugular intrahepatic portosystemic shunt (TIPS) placement. Clinical Presentation and Intervention: The 2 patients had a history of alcoholic cirrhosis, and TIPS surgery was performed on them. In both cases, 4 mont...

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Bibliographic Details
Published in:Medical principles and practice 2017-01, Vol.26 (3), p.286-288
Main Authors: Hernández-Jaras, Julio, Espí-Reig, Jordi, Alis, Rafael, García-Martínez, Ana-Maria, Rodríguez-Ortega, Diego, Roca-Argente, Lourdes, Moll-Guillen, Jose-Luis
Format: Article
Language:English
Subjects:
Antigen-Antibody Complex - immunology
Biopsy
Case 2
Case Report
Case reports
Congenital diseases
Female
Glomerulonephritis, Membranoproliferative - etiology
Glomerulonephritis, Membranoproliferative - immunology
Humans
Hypertension
Immune Complex Diseases - etiology
Immune Complex Diseases - immunology
Kidneys
Liver cirrhosis
Liver Cirrhosis, Alcoholic - surgery
Liver diseases
Male
Middle Aged
Patients
Portasystemic Shunt, Transjugular Intrahepatic - adverse effects
Veins & arteries
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Summary:Objective: To report on 2 patients with alcoholic cirrhosis who were treated with transjugular intrahepatic portosystemic shunt (TIPS) placement. Clinical Presentation and Intervention: The 2 patients had a history of alcoholic cirrhosis, and TIPS surgery was performed on them. In both cases, 4 months after TIPS placement, proteinuria was observed along with histological alterations characteristic of immune complex membranoproliferative glomerulonephritis (MPGN). Conclusion: The TIPS in one patient was successful without immediate complications, while the other patient was referred for a combined liver-kidney transplant. In both cases, immune complex MPGN might have developed after TIPS placement probably due to a reduced immune complex clearance.
ISSN:1011-7571
1423-0151
DOI:10.1159/000464365