Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice

• Published in: Scientific reports 2017-09, Vol.7 (1), p.10847-13, Article 10847
• Main Authors: Zhang, Chen, Li, Juan, Hu, Chunlong, Wang, Jing, Zhang, Jianjun, Ren, Zhenzhen, Song, Xinling, Jia, Le
• Format: Article
• Language: English
• Subjects: 631/326/193/2538; 631/326/2522; 64/60; Alanine; Alanine transaminase; Alkaline phosphatase; alpha-Amylases - antagonists & inhibitors; alpha-Glucosidases - metabolism; Animals; Antioxidants; Aspartate aminotransferase; Basidiomycota - chemistry; Biomarkers; Catalase; Creatinine; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental; Dietary supplements; Disease Models, Animal; Functional foods & nutraceuticals; Fungal Polysaccharides - pharmacology; Glutathione peroxidase; Glycoside Hydrolase Inhibitors; Humanities and Social Sciences; Hypoglycemic Agents - pharmacology; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidneys; Liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Mice; multidisciplinary; Mycelia; Oxidation-Reduction; Pancreas; Pancreas - drug effects; Pancreas - metabolism; Pancreas - pathology; Polysaccharides; Protective Agents - pharmacology; Rodents; Saccharides; Science; Science (multidisciplinary); Spectrum Analysis; Streptozocin; Superoxide dismutase; Urea
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-11457-w

The present work was designed to investigate the antihyperglycaemic and protective effects of two Hericium erinaceus intracellular polysaccharide (HIPS) purified fractions (HIPS1 and HIPS2) from mycelia of H. erinaceus SG-02 on pancreas, liver and kidney in streptozotocin (STZ)-induced diabetic mice. The supplementation of HIPS1 and HIPS2 significantly decreased the blood glucose (GLU) levels; suppressed the abnormal elevations of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN) and creatinine (CRE) levels in serum; improved the antioxidant enzymatic (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)) activities; and attenuated the pathological damage to these organs. The HIPS1 showed superior effects in antihyperglycaemia and organic protection than HIPS2 possible owing to the abundant functional groups (-NH 2 , -COOH and S=O) in HIPS1, indicating that H. erinaceus SG-02 could be used as a functional food and natural drug for the prevention of diabetes and its complications.