Multifaceted interactions between adaptive immunity and the central nervous system

Neuroimmunologists seek to understand the interactions between the central nervous system (CNS) and the immune system, both under homeostatic conditions and in diseases. Unanswered questions include those relating to the diversity and specificity of the meningeal T cell repertoire; the routes taken...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2016-08, Vol.353 (6301), p.766-771
Main Author: Kipnis, Jonathan
Format: Article
Language:English
Subjects:
Adaptive Immunity
Adaptive systems
Allergy and Immunology - trends
Central nervous system
Central Nervous System - immunology
Central Nervous System - injuries
Cognition Disorders - immunology
Evolutionary
Homeostasis - immunology
Humans
Immune system
Immune System - cytology
Immune System - immunology
Immune systems
Immunity
Immunologic Surveillance
Links
Meninges - immunology
Nervous system
Neurology - trends
Pathology
Patrols
REVIEW
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Summary:Neuroimmunologists seek to understand the interactions between the central nervous system (CNS) and the immune system, both under homeostatic conditions and in diseases. Unanswered questions include those relating to the diversity and specificity of the meningeal T cell repertoire; the routes taken by immune cells that patrol the méninges under healthy conditions and invade the parenchyma during pathology; the opposing effects (beneficial or detrimental) of these cells on CNS function; the role of immune cells after CNS injury; and the evolutionary link between the two systems, resulting in their tight interaction and interdependence. This Review summarizes the current standing of and challenging questions related to interactions between adaptive immunity and the CNS and considers the possible directions in which these aspects of neuroimmunology will be heading over the next decade.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aag2638