Field-Effect Transistor Biosensor for Rapid Detection of Ebola Antigen

The Ebola virus transmits a highly contagious, frequently fatal human disease for which there is no specific antiviral treatment. Therefore, rapid, accurate, and early diagnosis of Ebola virus disease (EVD) is critical to public health containment efforts, particularly in developing countries where...

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Bibliographic Details
Published in:Scientific reports 2017-09, Vol.7 (1), p.10974-8, Article 10974
Main Authors: Chen, Yantao, Ren, Ren, Pu, Haihui, Guo, Xiaoru, Chang, Jingbo, Zhou, Guihua, Mao, Shun, Kron, Michael, Chen, Junhong
Format: Article
Language:English
Subjects:
639/301/357/1018
639/925/927/356
Antigens
Biosensors
Developing countries
Ebola virus
Ebolavirus
Epidemics
Fabrication
Humanities and Social Sciences
LDCs
multidisciplinary
Public health
Science
Science (multidisciplinary)
Transistors
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Summary:The Ebola virus transmits a highly contagious, frequently fatal human disease for which there is no specific antiviral treatment. Therefore, rapid, accurate, and early diagnosis of Ebola virus disease (EVD) is critical to public health containment efforts, particularly in developing countries where resources are few and EVD is endemic. We have developed a reduced graphene oxide-based field-effect transistor method for real-time detection of the Ebola virus antigen. This method uses the attractive semiconductor characteristics of graphene-based material, and instantaneously yields highly sensitive and specific detection of Ebola glycoprotein. The feasibility of this method for clinical application in point-of-care technology is evaluated using Ebola glycoprotein suspended in diluted PBS buffer, human serum, and plasma. These results demonstrate the successful fabrication of a promising field-effect transistor biosensor for EVD diagnosis.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-11387-7