Monitoring Leiomyoma Response to Uterine Artery Embolization Using Diffusion and Perfusion Indices from Diffusion-Weighted Imaging

Purpose. To investigate the potential of diffusion and perfusion indices (ADC and perfusion fraction f) from DWI at 3.0 T in monitoring treatment response to uterine artery embolization (UAE) at 6-month follow-up. Methods. Twelve female patients with uterine fibroids who underwent 3.0-T pelvic DWI b...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-7
Main Authors: Xu, Jianrong, Suo, Shiteng, Zhou, Yan, Liu, Jialin, Zhao, Huilin, Lu, Qing, Suo, Xinjun, Zhang, Xuebin, Qian, Lijun, Cao, Mengqiu, Qu, Jian-Xun
Format: Article
Language:English
Subjects:
Abdomen
Adult
Diffusion
Diffusion Magnetic Resonance Imaging - methods
Embolization
Female
Fibroids
Follow-Up Studies
Humans
Hysterectomy
Leiomyoma - diagnostic imaging
Leiomyoma - therapy
Middle Aged
Monitoring
NMR
Nuclear magnetic resonance
Perfusion
Statistical tests
Studies
Treatment Outcome
Uterine Artery Embolization - adverse effects
Uterine Neoplasms - diagnostic imaging
Uterine Neoplasms - therapy
Uterus
Veins & arteries
Young Adult
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Summary:Purpose. To investigate the potential of diffusion and perfusion indices (ADC and perfusion fraction f) from DWI at 3.0 T in monitoring treatment response to uterine artery embolization (UAE) at 6-month follow-up. Methods. Twelve female patients with uterine fibroids who underwent 3.0-T pelvic DWI before and 6 months after UAE were included. ADC and perfusion fraction f were calculated from DWI. The Wilcoxon signed-rank test and Spearman rank correlation test were used for statistics. Results. Seventeen fibroids were studied. The median ADCs showed a significant increase from 1.20 × 10−3 mm2/s (range, 0.86–1.66 × 10−3 mm2/s) at baseline to 1.56 × 10−3 mm2/s (range, 1.00–1.86 × 10−3 mm2/s) at 6-month follow-up (P=0.0003). Conversely, the median perfusion fraction f was significantly decreased after UAE (P=0.0001), with a median pre-UAE value of 14.2% (range, 6.7%–17.6%) and a median post-UAE value of 9.2% (range, 3.2%–14.6%). Significant correlations were found between fibroid volume reduction rate and percentage changes in ADC and perfusion fraction f at 6-month follow-up relative to baseline, with ρ values of −0.50 (P=0.04) and 0.55 (P=0.02), respectively. Conclusion. ADC and perfusion fraction f obtained from DWI at 3.0 T may help to evaluate treatment response to UAE.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/3805073