Effects of Probiotics on Necrotizing Enterocolitis, Sepsis, Intraventricular Hemorrhage, Mortality, Length of Hospital Stay, and Weight Gain in Very Preterm Infants: A Meta-Analysis

Probiotics are increasingly used as a supplement to prevent adverse health outcomes in preterm infants. We conducted a systematic review, meta-analysis, and subgroup analysis of findings from randomized controlled trials (RCTs) to assess the magnitude of the effect of the probiotics on health outcom...

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Bibliographic Details
Published in:Advances in nutrition (Bethesda, Md.) Md.), 2017-09, Vol.8 (5), p.749-763
Main Authors: Sun, Jing, Marwah, Gayatri, Westgarth, Matthew, Buys, Nicholas, Ellwood, David, Gray, Peter H
Format: Article
Language:English
Subjects:
Dietary Supplements
Enterocolitis, Necrotizing - mortality
Enterocolitis, Necrotizing - prevention & control
Hemorrhage - mortality
Hemorrhage - prevention & control
hospital admission
Humans
Incidence
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - mortality
Infant, Premature, Diseases - prevention & control
Length of Stay
mortality
necrotizing enterocolitis
probiotics
Probiotics - administration & dosage
Randomized Controlled Trials as Topic
Reviews
sepsis
Sepsis - mortality
Sepsis - prevention & control
Treatment Outcome
very preterm infants
Weight Gain
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Summary:Probiotics are increasingly used as a supplement to prevent adverse health outcomes in preterm infants. We conducted a systematic review, meta-analysis, and subgroup analysis of findings from randomized controlled trials (RCTs) to assess the magnitude of the effect of the probiotics on health outcomes among very-low–birth-weight (VLBW) infants. Relevant articles from January 2003 to June 2017 were selected from a broad range of databases, including Medline, PubMed, Scopus, and Embase. Studies were included if they used an RCT design, involved a VLBW infant (birthweight
ISSN:2161-8313
2156-5376
DOI:10.3945/an.116.014605