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MEG biomarker of Alzheimer's disease: Absence of a prefrontal generator during auditory sensory gating

Magnetoencephalography (MEG), a direct measure of neuronal activity, is an underexplored tool in the search for biomarkers of Alzheimer's disease (AD). In this study, we used MEG source estimates of auditory gating generators, nonlinear correlations with neuropsychological results, and multivar...

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Published in:Human brain mapping 2017-10, Vol.38 (10), p.5180-5194
Main Authors: Josef Golubic, Sanja, Aine, Cheryl J., Stephen, Julia M., Adair, John C., Knoefel, Janice E., Supek, Selma
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description Magnetoencephalography (MEG), a direct measure of neuronal activity, is an underexplored tool in the search for biomarkers of Alzheimer's disease (AD). In this study, we used MEG source estimates of auditory gating generators, nonlinear correlations with neuropsychological results, and multivariate analyses to examine the sensitivity and specificity of gating topology modulation to detect AD. Our results demonstrated the use of MEG localization of a medial prefrontal (mPFC) gating generator as a discrete (binary) detector of AD at the individual level and resulted in recategorizing the participant categories in: (1) controls with mPFC generator localized in response to both the standard and deviant tones; (2) a possible preclinical stage of AD participants (a lower functioning group of controls) in which mPFC activation was localized to the deviant tone only; and (3) symptomatic AD in which mPFC activation was not localized to either the deviant or standard tones. This approach showed a large effect size (0.9) and high accuracy, sensitivity, and specificity (100%) in identifying symptomatic AD patients within a limited research sample. The present results demonstrate high potential of mPFC activation as a noninvasive biomarker of AD pathology during putative preclinical and clinical stages. Hum Brain Mapp 38:5180–5194, 2017. © 2017 Wiley Periodicals, Inc.
doi_str_mv 10.1002/hbm.23724
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subjects Acoustic Stimulation
Activation
Aged
Aged, 80 and over
Alzheimer Disease - diagnosis
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - physiopathology
Alzheimer Disease - psychology
Alzheimer's disease
Auditory perception
Auditory Perception - physiology
auditory sensory gating
biomarker
Biomarkers
Brain
Cluster Analysis
dementia
Female
Gating
Generators
Humans
Localization
Magnetic Resonance Imaging
Magnetoencephalography
Male
Middle Aged
mild cognitive impairment
Neurodegenerative diseases
neuroimaging
Neuropsychological Tests
preclinical Alzheimer's disease
prefrontal cortex
Prefrontal Cortex - diagnostic imaging
Prefrontal Cortex - physiopathology
Principal Component Analysis
Rey–Osterreith complex figure test
Sensitivity
Sensitivity analysis
Sensitivity and Specificity
Sensory Gating - physiology
Signal Processing, Computer-Assisted
Topology
title MEG biomarker of Alzheimer's disease: Absence of a prefrontal generator during auditory sensory gating
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