Associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms, lifestyles and hypertension risk in Chinese Han people

• Published in: Scientific reports 2017-09, Vol.7 (1), p.11136-8, Article 11136
• Main Authors: Ma, Cong, Yu, Bingxiang, Zhang, Weihua, Wang, Weimin, Zhang, Liping, Zeng, Qiang
• Format: Article
• Language: English
• Subjects: 38; 38/23; 692/499; 692/700/478/174; Acetaldehyde; Adult; Aldehyde dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial - genetics; Alleles; Asian Continental Ancestry Group - genetics; Biomarkers; Blood pressure; Case-Control Studies; China - epidemiology; Food; Food consumption; Food intake; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Genotypes; Humanities and Social Sciences; Humans; Hypertension; Hypertension - epidemiology; Hypertension - etiology; Hypertension - metabolism; Kidney Function Tests; Life Style; Lifestyles; Liver Function Tests; Middle Aged; multidisciplinary; Odds Ratio; Polymerase chain reaction; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-11071-w

Hypertension is a multiple factor disease which was influenced by gene, environment, and lifestyle. Several studies confirmed that the ALDH2 rs671 polymorphism is associated with hypertension. However, the evidence remains inconclusive. Whether lifestyle affects blood pressure in different genotype groups have not been clarified, either. The subjects were adult Chinese Han people who received health examination in the period from December 2014 to December 2015. Detection of the ALDH2 r671 polymorphism was determined by polymerase chain reaction. Lifestyle data were collected using self-administered questionnaires. Basic characteristics and fasting venous blood sample were collected at baseline. 4018 subjects were eligible for participation.The frequencies of the ALDH2 rs671 genotype were 68.67% (GG), 28.67%(GL), 2.66%(LL), respectively. Pepole who harbored the L allele were less likely to develop incident hypertension. There was a significant association between food frequency and hypertension in the L genotype group. Fried food intake was significantly increased the risk of hypertension in the L genotype group. Our study suggested that ALDH2 rs671 L-genotypes are protective factors for hypertension in Han Chinese. Consumption of fried food accelerated the development of hypertension in individuals with poor metabolism of acetaldehyde.