PM2.5 exposure in utero contributes to neonatal cardiac dysfunction in mice

Exposure of fine particulate matter (PM2.5) to pregnant dams has been shown to be strongly associated with adverse cardiovascular outcomes in offspring at adulthood, however, effects evident during neonatal periods are unclear. We designed this study to examine cardiac function of neonatal mice (14...

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Bibliographic Details
Published in:Environmental pollution (1987) 2017-11, Vol.230, p.116-124
Main Authors: Tanwar, Vineeta, Adelstein, Jeremy M., Grimmer, Jacob A., Youtz, Dane J., Sugar, Benjamin P., Wold, Loren E.
Format: Article
Language:English
Subjects:
Adolescence
adulthood
air
calcium
Calcium signaling
cardiac output
cardiomyocytes
Cardiovascular function
females
fluorescence
gestation period
Heart failure
immunoblotting
In utero
mice
Myocyte
neonates
Particulate matter
particulates
progeny
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Summary:Exposure of fine particulate matter (PM2.5) to pregnant dams has been shown to be strongly associated with adverse cardiovascular outcomes in offspring at adulthood, however, effects evident during neonatal periods are unclear. We designed this study to examine cardiac function of neonatal mice (14 days old) exposed to in utero PM2.5. Pregnant FVB female mice were exposed either to filtered air (FA) or PM2.5 at an average concentration of 91.78 μg/m3 for 6 h/day, 5 days/wk (similar to exposure in a large industrial area) throughout the gestation period (21 days). After birth, animals were analyzed at day 14 of life. Fourteen day old mice exposed to PM2.5 during the in utero period demonstrated decreased fractional shortening (%FS, 41.1 ± 1.2% FA, 33.7 ± 1.2% PM2.5, p 
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2017.06.035