RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis

• Published in: Cell death & disease 2017-08, Vol.8 (8), p.e2994-e2994
• Main Authors: Geng, Rong, Tan, Xin, Wu, Jiangxue, Pan, Zhizhong, Yi, Min, Shi, Wei, Liu, Ranyi, Yao, Chen, Wang, Gaoyuan, Lin, Jiaxin, Qiu, Lin, Huang, Wenlin, Chen, Shuai
• Format: Article
• Language: English
• Subjects: 13/1; 13/51; 13/89; 42/109; 631/337/572; 631/67/1504/1885; 631/67/322; 631/80/86; 64/60; Aged; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Movement - genetics; Cell Movement - physiology; Cell Proliferation - genetics; Cell Proliferation - physiology; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Female; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Humans; Immunology; Interleukin-8 - metabolism; Life Sciences; Male; Middle Aged; Neoplasm Metastasis - genetics; NF-kappa B - metabolism; Original; original-article; Signal Transduction - genetics; Signal Transduction - physiology; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/cddis.2017.400

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, which is a heterogeneous disease and main risk factors are associated with inflammation, family history, genetic mutations, epigenetics, and so on. Ring finger domain proteins have been reported involved in carcinogenesis, whereas their roles in CRC are rarely studied. Here, we reanalyzed the expression of 202 RNF family members in CRC using published microarray data from GEO database and found that RNF183 is markedly upregulated in tumor tissues. RNF183 high expression is significantly associated with tumor size ( P =0.012), tumor invasive depth ( P =0.004), TNM stage ( P =0.01), and distant metastasis ( P =0.009). CRC patients with high expression of RNF183 have poor overall survival ( P