Enzyme-based amperometric galactose biosensors: a review

This review (with 35 references) summarizes the various strategies used in biosensors for galactose, and their analytical performance. A brief comparison of the enzyme immobilization methods employed and the analytical performance characteristics of a range of galactose biosensors are first summariz...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2017-10, Vol.184 (10), p.3663-3671
Main Authors: Kanyong, Prosper, Krampa, Francis D., Aniweh, Yaw, Awandare, Gordon A.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biosensing Techniques - methods
Biosensors
Characterization and Evaluation of Materials
Chemical bonds
Chemistry
Chemistry and Materials Science
Comparative analysis
Crosslinking
Electrical measurement
Electrochemical Techniques - methods
Entrapment
Enzymes
Enzymes, Immobilized - chemistry
Galactose
Galactose - blood
Galactose - chemistry
Galactose Dehydrogenases - chemistry
Galactose Oxidase - chemistry
Humans
Immobilization
Medical equipment
Microengineering
Nanochemistry
Nanotechnology
Oxidase
Oxidases
Physiological apparatus
Review
Review Article
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Summary:This review (with 35 references) summarizes the various strategies used in biosensors for galactose, and their analytical performance. A brief comparison of the enzyme immobilization methods employed and the analytical performance characteristics of a range of galactose biosensors are first summarized in tabular form and then described in detail. Selected examples have been included to demonstrate the various applications of these biosensors to real samples. Following an introduction into the field that covers the significance of sensing galactose in various fields, the review covers biosensors based on the use of galactose oxidase, with a discussion of methods for their immobilization (via cross-linking, adsorption, covalent bonding and entrapment). This is followed by a short section on biosensors based on the use of galactose dehydrogenase. The conclusion section summarizes the state of the art and addresses current challenges. Graphical abstract Fabrication of a disposable screen-printed (a) electrochemical galactose biosensor (b) for real sample analysis and a dummy biosensor (c) for compensating the effect of interferences
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-017-2465-z