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European Veterinary Renal Pathology Service: A Survey Over a 7‐Year Period (2008–2015)
Background The European Veterinary Renal Pathology Service (EVRPS) is the first Web‐based registry for canine renal biopsy specimens in Europe. Hypothesis/Objectives The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to...
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Published in: | Journal of veterinary internal medicine 2017-09, Vol.31 (5), p.1459-1468 |
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creator | Aresu, L. Martini, V. Benali, S.L. Brovida, C. Cianciolo, R.E. Dalla Riva, R. Trez, D. Van Der Lugt, J.J. Van Dongen, A. Zini, E. |
description | Background
The European Veterinary Renal Pathology Service (EVRPS) is the first Web‐based registry for canine renal biopsy specimens in Europe.
Hypothesis/Objectives
The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS.
Animals
Renal biopsy specimens of dogs were collected from the archive of the service (n = 254). Cases were included if both light and electron microscopy were available (n = 162).
Methods
Renal biopsy specimens were classified based on the morphological diagnoses. Thereafter, they were grouped into 3 disease categories, including immune‐complex‐mediated glomerulonephritis (ICGN), non‐immune‐complex‐mediated GN (non‐ICGN), and renal lesions not otherwise specified (RL‐NOS). Differences among morphological diagnoses and among disease categories were investigated for clinical and laboratory variables.
Results
Serum albumin concentration was lower in dogs with ICGN than in those with non‐ICGN (P = 0.006) or RL‐NOS (P = 0.000), and the urine protein‐to‐creatinine ratio (UPC) was significantly higher in ICGN than in the other 2 disease categories. Regarding morphological diagnoses, albumin was significantly lower in amyloidosis (AMY) and membranous (MGN), membranoproliferative (MPGN) or mixed glomerulonephritis (MixGN) than in minimal change disease, primary (FSGS I) or secondary (FSGS II) focal and segmental glomerulosclerosis and juvenile nephropathies (JN). The UPC was higher in MPGN than in FSGS I and FSGS II.
Conclusions and clinical importance
Dogs with ICGN, in particular MPGN, had higher protein loss than those with non‐ICGN or RL‐NOS, leading to more severe hypoalbuminemia. Clinical and laboratory differentiation among dogs with the different morphological diagnoses and among dogs with different disease categories was difficult due to overlapping results. |
doi_str_mv | 10.1111/jvim.14796 |
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fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5598877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1925274767</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4866-5da3fcda5a994e8cc1f19eb8d04c4712f0a4407ee019c3b2d5672093608b07453</originalsourceid><addsrcrecordid>eNp9kctO3DAUhi0EYobLhgdAXtJKAdvxlUUlhLhVVIzKRaIby-OcQFAST51J0Ox4BCTekCdphqGobHo2XpzPn8_xj9AWJbu0r72Hrqh2KVdGLqEhNalJqFRyGQ2JNjSRkpMBWmuaB0KYEEKtogHTSqaUqSH6ddTGMAFX4xuYQixqF2f4J9SuxCM3vQ9luJvhS4hd4WEfH-DLNnYwwxcdROywen16vgUX8ai_GjK8wwjRr08vjFDxZQOt5K5sYPP9XEfXx0dXh6fJ-cXJ2eHBeeK5ljIRmUtznznhjOGgvac5NTDWGeGeK8py4jgnCoBQ49Mxy4RUjJhUEj0miot0HX1beCftuILMQz2NrrSTWFT9Mja4wn7u1MW9vQudFcJorVQv2HkXxPC7hWZqq6LxUJauhtA2lhommOJKztGvC9TH0DQR8o9nKLHzMOw8DPsWRg9v_zvYB_r393uALoDHooTZf1T2-83Zj4X0D0gRlVk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1925274767</pqid></control><display><type>article</type><title>European Veterinary Renal Pathology Service: A Survey Over a 7‐Year Period (2008–2015)</title><source>PubMed Central (Open Access)</source><source>Wiley-Blackwell Open Access Titles(OpenAccess)</source><creator>Aresu, L. ; Martini, V. ; Benali, S.L. ; Brovida, C. ; Cianciolo, R.E. ; Dalla Riva, R. ; Trez, D. ; Van Der Lugt, J.J. ; Van Dongen, A. ; Zini, E.</creator><creatorcontrib>Aresu, L. ; Martini, V. ; Benali, S.L. ; Brovida, C. ; Cianciolo, R.E. ; Dalla Riva, R. ; Trez, D. ; Van Der Lugt, J.J. ; Van Dongen, A. ; Zini, E.</creatorcontrib><description>Background
The European Veterinary Renal Pathology Service (EVRPS) is the first Web‐based registry for canine renal biopsy specimens in Europe.
Hypothesis/Objectives
The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS.
Animals
Renal biopsy specimens of dogs were collected from the archive of the service (n = 254). Cases were included if both light and electron microscopy were available (n = 162).
Methods
Renal biopsy specimens were classified based on the morphological diagnoses. Thereafter, they were grouped into 3 disease categories, including immune‐complex‐mediated glomerulonephritis (ICGN), non‐immune‐complex‐mediated GN (non‐ICGN), and renal lesions not otherwise specified (RL‐NOS). Differences among morphological diagnoses and among disease categories were investigated for clinical and laboratory variables.
Results
Serum albumin concentration was lower in dogs with ICGN than in those with non‐ICGN (P = 0.006) or RL‐NOS (P = 0.000), and the urine protein‐to‐creatinine ratio (UPC) was significantly higher in ICGN than in the other 2 disease categories. Regarding morphological diagnoses, albumin was significantly lower in amyloidosis (AMY) and membranous (MGN), membranoproliferative (MPGN) or mixed glomerulonephritis (MixGN) than in minimal change disease, primary (FSGS I) or secondary (FSGS II) focal and segmental glomerulosclerosis and juvenile nephropathies (JN). The UPC was higher in MPGN than in FSGS I and FSGS II.
Conclusions and clinical importance
Dogs with ICGN, in particular MPGN, had higher protein loss than those with non‐ICGN or RL‐NOS, leading to more severe hypoalbuminemia. Clinical and laboratory differentiation among dogs with the different morphological diagnoses and among dogs with different disease categories was difficult due to overlapping results.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.14796</identifier><identifier>PMID: 28763127</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Animals ; Biopsy - veterinary ; Diagnosis ; Dog ; Dog Diseases - pathology ; Dogs ; Electron microscopy ; Europe ; Female ; Glomerulonephritis ; Glomerulonephritis - pathology ; Glomerulonephritis - veterinary ; Kidney - pathology ; Kidney Diseases - pathology ; Kidney Diseases - veterinary ; Male ; Microscopy - veterinary ; Microscopy, Electron - veterinary ; Registries ; Renal biopsy ; SMALL ANIMAL ; Surveys and Questionnaires</subject><ispartof>Journal of veterinary internal medicine, 2017-09, Vol.31 (5), p.1459-1468</ispartof><rights>Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4866-5da3fcda5a994e8cc1f19eb8d04c4712f0a4407ee019c3b2d5672093608b07453</citedby><cites>FETCH-LOGICAL-c4866-5da3fcda5a994e8cc1f19eb8d04c4712f0a4407ee019c3b2d5672093608b07453</cites><orcidid>0000-0002-7893-1740</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598877/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598877/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,27924,27925,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28763127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aresu, L.</creatorcontrib><creatorcontrib>Martini, V.</creatorcontrib><creatorcontrib>Benali, S.L.</creatorcontrib><creatorcontrib>Brovida, C.</creatorcontrib><creatorcontrib>Cianciolo, R.E.</creatorcontrib><creatorcontrib>Dalla Riva, R.</creatorcontrib><creatorcontrib>Trez, D.</creatorcontrib><creatorcontrib>Van Der Lugt, J.J.</creatorcontrib><creatorcontrib>Van Dongen, A.</creatorcontrib><creatorcontrib>Zini, E.</creatorcontrib><title>European Veterinary Renal Pathology Service: A Survey Over a 7‐Year Period (2008–2015)</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
The European Veterinary Renal Pathology Service (EVRPS) is the first Web‐based registry for canine renal biopsy specimens in Europe.
Hypothesis/Objectives
The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS.
Animals
Renal biopsy specimens of dogs were collected from the archive of the service (n = 254). Cases were included if both light and electron microscopy were available (n = 162).
Methods
Renal biopsy specimens were classified based on the morphological diagnoses. Thereafter, they were grouped into 3 disease categories, including immune‐complex‐mediated glomerulonephritis (ICGN), non‐immune‐complex‐mediated GN (non‐ICGN), and renal lesions not otherwise specified (RL‐NOS). Differences among morphological diagnoses and among disease categories were investigated for clinical and laboratory variables.
Results
Serum albumin concentration was lower in dogs with ICGN than in those with non‐ICGN (P = 0.006) or RL‐NOS (P = 0.000), and the urine protein‐to‐creatinine ratio (UPC) was significantly higher in ICGN than in the other 2 disease categories. Regarding morphological diagnoses, albumin was significantly lower in amyloidosis (AMY) and membranous (MGN), membranoproliferative (MPGN) or mixed glomerulonephritis (MixGN) than in minimal change disease, primary (FSGS I) or secondary (FSGS II) focal and segmental glomerulosclerosis and juvenile nephropathies (JN). The UPC was higher in MPGN than in FSGS I and FSGS II.
Conclusions and clinical importance
Dogs with ICGN, in particular MPGN, had higher protein loss than those with non‐ICGN or RL‐NOS, leading to more severe hypoalbuminemia. Clinical and laboratory differentiation among dogs with the different morphological diagnoses and among dogs with different disease categories was difficult due to overlapping results.</description><subject>Animals</subject><subject>Biopsy - veterinary</subject><subject>Diagnosis</subject><subject>Dog</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Electron microscopy</subject><subject>Europe</subject><subject>Female</subject><subject>Glomerulonephritis</subject><subject>Glomerulonephritis - pathology</subject><subject>Glomerulonephritis - veterinary</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - veterinary</subject><subject>Male</subject><subject>Microscopy - veterinary</subject><subject>Microscopy, Electron - veterinary</subject><subject>Registries</subject><subject>Renal biopsy</subject><subject>SMALL ANIMAL</subject><subject>Surveys and Questionnaires</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp9kctO3DAUhi0EYobLhgdAXtJKAdvxlUUlhLhVVIzKRaIby-OcQFAST51J0Ox4BCTekCdphqGobHo2XpzPn8_xj9AWJbu0r72Hrqh2KVdGLqEhNalJqFRyGQ2JNjSRkpMBWmuaB0KYEEKtogHTSqaUqSH6ddTGMAFX4xuYQixqF2f4J9SuxCM3vQ9luJvhS4hd4WEfH-DLNnYwwxcdROywen16vgUX8ai_GjK8wwjRr08vjFDxZQOt5K5sYPP9XEfXx0dXh6fJ-cXJ2eHBeeK5ljIRmUtznznhjOGgvac5NTDWGeGeK8py4jgnCoBQ49Mxy4RUjJhUEj0miot0HX1beCftuILMQz2NrrSTWFT9Mja4wn7u1MW9vQudFcJorVQv2HkXxPC7hWZqq6LxUJauhtA2lhommOJKztGvC9TH0DQR8o9nKLHzMOw8DPsWRg9v_zvYB_r393uALoDHooTZf1T2-83Zj4X0D0gRlVk</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Aresu, L.</creator><creator>Martini, V.</creator><creator>Benali, S.L.</creator><creator>Brovida, C.</creator><creator>Cianciolo, R.E.</creator><creator>Dalla Riva, R.</creator><creator>Trez, D.</creator><creator>Van Der Lugt, J.J.</creator><creator>Van Dongen, A.</creator><creator>Zini, E.</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7893-1740</orcidid></search><sort><creationdate>201709</creationdate><title>European Veterinary Renal Pathology Service: A Survey Over a 7‐Year Period (2008–2015)</title><author>Aresu, L. ; Martini, V. ; Benali, S.L. ; Brovida, C. ; Cianciolo, R.E. ; Dalla Riva, R. ; Trez, D. ; Van Der Lugt, J.J. ; Van Dongen, A. ; Zini, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4866-5da3fcda5a994e8cc1f19eb8d04c4712f0a4407ee019c3b2d5672093608b07453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biopsy - veterinary</topic><topic>Diagnosis</topic><topic>Dog</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Electron microscopy</topic><topic>Europe</topic><topic>Female</topic><topic>Glomerulonephritis</topic><topic>Glomerulonephritis - pathology</topic><topic>Glomerulonephritis - veterinary</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - veterinary</topic><topic>Male</topic><topic>Microscopy - veterinary</topic><topic>Microscopy, Electron - veterinary</topic><topic>Registries</topic><topic>Renal biopsy</topic><topic>SMALL ANIMAL</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aresu, L.</creatorcontrib><creatorcontrib>Martini, V.</creatorcontrib><creatorcontrib>Benali, S.L.</creatorcontrib><creatorcontrib>Brovida, C.</creatorcontrib><creatorcontrib>Cianciolo, R.E.</creatorcontrib><creatorcontrib>Dalla Riva, R.</creatorcontrib><creatorcontrib>Trez, D.</creatorcontrib><creatorcontrib>Van Der Lugt, J.J.</creatorcontrib><creatorcontrib>Van Dongen, A.</creatorcontrib><creatorcontrib>Zini, E.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles(OpenAccess)</collection><collection>Wiley Online Library website</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aresu, L.</au><au>Martini, V.</au><au>Benali, S.L.</au><au>Brovida, C.</au><au>Cianciolo, R.E.</au><au>Dalla Riva, R.</au><au>Trez, D.</au><au>Van Der Lugt, J.J.</au><au>Van Dongen, A.</au><au>Zini, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>European Veterinary Renal Pathology Service: A Survey Over a 7‐Year Period (2008–2015)</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2017-09</date><risdate>2017</risdate><volume>31</volume><issue>5</issue><spage>1459</spage><epage>1468</epage><pages>1459-1468</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
The European Veterinary Renal Pathology Service (EVRPS) is the first Web‐based registry for canine renal biopsy specimens in Europe.
Hypothesis/Objectives
The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS.
Animals
Renal biopsy specimens of dogs were collected from the archive of the service (n = 254). Cases were included if both light and electron microscopy were available (n = 162).
Methods
Renal biopsy specimens were classified based on the morphological diagnoses. Thereafter, they were grouped into 3 disease categories, including immune‐complex‐mediated glomerulonephritis (ICGN), non‐immune‐complex‐mediated GN (non‐ICGN), and renal lesions not otherwise specified (RL‐NOS). Differences among morphological diagnoses and among disease categories were investigated for clinical and laboratory variables.
Results
Serum albumin concentration was lower in dogs with ICGN than in those with non‐ICGN (P = 0.006) or RL‐NOS (P = 0.000), and the urine protein‐to‐creatinine ratio (UPC) was significantly higher in ICGN than in the other 2 disease categories. Regarding morphological diagnoses, albumin was significantly lower in amyloidosis (AMY) and membranous (MGN), membranoproliferative (MPGN) or mixed glomerulonephritis (MixGN) than in minimal change disease, primary (FSGS I) or secondary (FSGS II) focal and segmental glomerulosclerosis and juvenile nephropathies (JN). The UPC was higher in MPGN than in FSGS I and FSGS II.
Conclusions and clinical importance
Dogs with ICGN, in particular MPGN, had higher protein loss than those with non‐ICGN or RL‐NOS, leading to more severe hypoalbuminemia. Clinical and laboratory differentiation among dogs with the different morphological diagnoses and among dogs with different disease categories was difficult due to overlapping results.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>28763127</pmid><doi>10.1111/jvim.14796</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7893-1740</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals Biopsy - veterinary Diagnosis Dog Dog Diseases - pathology Dogs Electron microscopy Europe Female Glomerulonephritis Glomerulonephritis - pathology Glomerulonephritis - veterinary Kidney - pathology Kidney Diseases - pathology Kidney Diseases - veterinary Male Microscopy - veterinary Microscopy, Electron - veterinary Registries Renal biopsy SMALL ANIMAL Surveys and Questionnaires |
title | European Veterinary Renal Pathology Service: A Survey Over a 7‐Year Period (2008–2015) |
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