Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits

Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioura...

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Bibliographic Details
Published in:Scientific reports 2017-09, Vol.7 (1), p.11655-7, Article 11655
Main Authors: Howe, Laurence J., Erzurumluoglu, A. Mesut, Davey Smith, George, Rodriguez, Santiago, Stergiakouli, Evie
Format: Article
Language:English
Subjects:
45
45/23
631/208/726/2129
631/477/2811
Child
Child Behavior
Childhood
Children
Chromosomes
Chromosomes, Human, Y
Cognition
Deoxyribonucleic acid
DNA
DNA, Mitochondrial
Female
Genetic Association Studies
Haplotypes
Humanities and Social Sciences
Humans
Longitudinal studies
Male
Males
Mitochondrial DNA
multidisciplinary
Odds Ratio
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait, Heritable
Science
Science (multidisciplinary)
Sex chromosomes
Sexual behavior
Sexual dimorphism
Y chromosomes
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Summary:Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom. Different subsets of these populations were assessed using measures of behavioural and psychiatric traits with logistic regression being used to measure the association between haplogroups and the traits. The majority of behavioural traits in our cohort differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with any of the variables. These findings suggest that if there is common variation on the Y chromosome and mitochondrial DNA associated with behavioural and psychiatric trait variation, it has a small effect.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-10871-4