Modulating NAD+ metabolism, from bench to bedside

Discovered in the beginning of the 20 th century, nicotinamide adenine dinucleotide (NAD + ) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD + ‐dependent protein deacylases, widely reco...

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Bibliographic Details
Published in:The EMBO journal 2017-09, Vol.36 (18), p.2670-2683
Main Authors: Katsyuba, Elena, Auwerx, Johan
Format: Article
Language:English
Subjects:
aging
Animals
Coenzymes - metabolism
EMBO21
EMBO24
Homeostasis
Humans
metabolic disorders
Metabolic Networks and Pathways
Mitochondria - metabolism
NAD - metabolism
neurodegeneration
nicotinamide adenine dinucleotide
poly ADP‐ribose polymerase
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Summary:Discovered in the beginning of the 20 th century, nicotinamide adenine dinucleotide (NAD + ) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD + ‐dependent protein deacylases, widely recognized regulators of metabolic function and longevity. Altered NAD + metabolism is associated with aging and many pathological conditions, such as metabolic diseases and disorders of the muscular and neuronal systems. Conversely, increased NAD + levels have shown to be beneficial in a broad spectrum of diseases. Here, we review the fundamental aspects of NAD + biochemistry and metabolism and discuss how boosting NAD + content can help ameliorate mitochondrial homeostasis and as such improve healthspan and lifespan. Graphical Abstract As part of our focus series on metabolism, this review discusses the physiological role of NAD + and the potential therapeutic effects of increasing NAD + levels.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.201797135