MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma

• Published in: Magnetic Resonance in Medical Sciences 2017, Vol.16(3), pp.223-230
• Main Authors: Ueda, Fumiaki, Aburano, Hiroyuki, Ryu, Yasuji, Yoshie, Yuichi, Nakada, Mitsutoshi, Hayashi, Yutaka, Matsui, Osamu, Gabata, Toshifumi
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Alanine; Brain diseases; Brain Neoplasms - diagnostic imaging; central neurocytoma; Choline; Creatine; Female; Glioma, Subependymal - diagnostic imaging; Glycine; Humans; Lactic acid; Magnetic Resonance Imaging - methods; Magnetic resonance spectroscopy; Magnetic Resonance Spectroscopy - methods; Major Paper; Male; Middle Aged; N-Acetylaspartate; Neurocytoma - diagnostic imaging; Numerical controls; Spectra; Spectroscopic analysis; Spectroscopy; Spectrum analysis; Statistical analysis; Statistical significance; supratentorial intraventricular subependymoma; Tumors; Young Adult
• ISSN: 1347-3182; 1880-2206
• DOI: 10.2463/mrms.mp.2015-0013

Purpose: The purpose of this study was to discriminate supratentorial intraventricular subependymoma (SIS) from central neurocytoma (CNC) using magnetic resonance spectroscopy (MRS).Methods: Single-voxel proton MRS using a 1.5T or 3T MR scanner from five SISs, five CNCs, and normal controls were evaluated. They were examined using a point-resolved spectroscopy. Automatically calculated ratios comparing choline (Cho), N-acetylaspartate (NAA), myoinositol (MI), and/or glycine (Gly) to creatine (Cr) were determined. Evaluation of Cr to unsuppressed water (USW) was also performed. Mann-Whitney U test was carried out to test the significance of differences in the metabolite ratios. Detectability of lactate (Lac) and alanine (Ala) was evaluated.Results: Although a statistically significant difference (P < 0.0001) was observed in Cho/Cr among SIS, control spectra, and CNC, no statistical difference was noted between SIS and control spectra (P = 0.11). Statistically significant differences were observed in NAA/Cr between SIS and CNC (P = 0.04) or control spectra (P < 0.0001). A statistically significant difference was observed in MI and/or Gly to Cr between SIS and control spectra (P = 0.03), and CNC and control spectra (P < 0.0006). There were no statistical differences between SIS and CNC for MI and/or Gly to Cr (P = 0.32). Significant statistical differences were found between SIS and control spectra (P < 0.0053), control spectra and CNC (P < 0.0016), and SIS and CNC (P < 0.0083) for Cr to USW. Lac inverted doublets were confirmed in two SISs. Triplets of Lac and Ala were detected in four spectra of CNC.Conclusion: The present study showed that MRS can be useful in discriminating SIS from CNC.