Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma

Purpose To investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG). Patients and methods Retrospective analysis of medical records of patients with open-angle glaucoma...

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Bibliographic Details
Published in:Eye (London) 2017-09, Vol.31 (9), p.1365-1372
Main Authors: Pircher, A, Montali, M, Berberat, J, Remonda, L, Killer, H E
Format: Article
Language:English
Subjects:
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Cerebrospinal fluid
Cerebrospinal Fluid Pressure - physiology
Clinical Study
Computed tomography
European Continental Ancestry Group
Female
Glaucoma
Humans
Intraocular Pressure - physiology
Laboratory Medicine
Low Tension Glaucoma - physiopathology
Male
Medical records
Medicine
Medicine & Public Health
Myelin Sheath - pathology
Ophthalmology
Optic nerve
Optic Nerve - diagnostic imaging
Optic Nerve - pathology
Pharmaceutical Sciences/Technology
Pressure
Retrospective Studies
Spinal Puncture
Statistical analysis
Subarachnoid Space
Surgery
Surgical Oncology
Tomography, X-Ray Computed
Tonometry, Ocular
Visual Field Tests
White people
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Summary:Purpose To investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG). Patients and methods Retrospective analysis of medical records of patients with open-angle glaucoma in the period from 2005 to 2015 from the Ophthalmology Department, Cantonal Hospital Aarau, Switzerland was performed. A total of 38 patients (mean age 68.6±11.3 years, 21 females and 17 males) fulfilled the diagnostic criteria of NTG and underwent computed tomography (CT) of the orbit and lumbar puncture (LP). In total, 38 age- and gender-matched Caucasian subjects (mean age: 68.9±10.9 years) without known ON diseases served as controls for ONSD measurements. ONSDs were measured at a distance of 3 mm from the posterior globe and lumbar CSF-p was related to the measurements. Statistical analysis was performed by using the independent two-tailed t -test and the non-parametric Spearman's correlation test. Results The mean ONSD in NTGs measured 6.4±0.9 mm and in controls 5.4±0.6 mm. The difference between NTGs and controls showed statistical significance ( t -test: P
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2017.70