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Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma
Purpose To investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG). Patients and methods Retrospective analysis of medical records of patients with open-angle glaucoma...
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| Published in: | Eye (London) 2017-09, Vol.31 (9), p.1365-1372 |
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| creator | Pircher, A Montali, M Berberat, J Remonda, L Killer, H E |
| description | Purpose
To investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG).
Patients and methods
Retrospective analysis of medical records of patients with open-angle glaucoma in the period from 2005 to 2015 from the Ophthalmology Department, Cantonal Hospital Aarau, Switzerland was performed. A total of 38 patients (mean age 68.6±11.3 years, 21 females and 17 males) fulfilled the diagnostic criteria of NTG and underwent computed tomography (CT) of the orbit and lumbar puncture (LP). In total, 38 age- and gender-matched Caucasian subjects (mean age: 68.9±10.9 years) without known ON diseases served as controls for ONSD measurements. ONSDs were measured at a distance of 3 mm from the posterior globe and lumbar CSF-p was related to the measurements. Statistical analysis was performed by using the independent two-tailed
t
-test and the non-parametric Spearman's correlation test.
Results
The mean ONSD in NTGs measured 6.4±0.9 mm and in controls 5.4±0.6 mm. The difference between NTGs and controls showed statistical significance (
t
-test:
P |
| doi_str_mv | 10.1038/eye.2017.70 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5601451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1893548130</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-af7134f5bed5ea3c67f3bf7fb7d4ce4cda29bc54252dc5188fe1c6dad52055e63</originalsourceid><addsrcrecordid>eNptkU1rFTEUhoMo9lpduZeAG0HnmmSSycymIMUvKBREwV3IJGfupMwkY5Jp6Q_wfzeXW0srXZ3F-_Ccw3kRek3JlpK6_QjXsGWEyq0kT9CGctlUggv-FG1IJ0jFGPt9hF6kdEFICSV5jo5YywXrOrJBf3_ApLMLPo1uwT3kKwCP8wg4LNkZ7CFeAk4j6Dxi6_QMGSLW3uJpnXsdsYEIfQxpcV5PeJhWZ_ESIaU1AnYeL8UOPid85YrBhzgXLINPZSfeTXo1YdYv0bNBTwle3c5j9OvL55-n36qz86_fTz-dVYbzJld6kLTmg-jBCtC1aeRQ94Mcemm5AW6sZl1vBGeCWSNo2w5ATWO1FYwIAU19jE4O3mXtZ7CmHBb1pJboZh2vVdBOPUy8G9UuXCrRlN8JWgTvbgUx_FkhZTW7ZGCatIewJkXbrha8pTUp6Nv_0IuwxvKkQnV1K2reSF6o9wfKlB-mCMPdMZSofb2q1Kv29Sq5d765f_8d-6_PAnw4AKlEfgfx3tJHfDfa8LSY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1938534674</pqid></control><display><type>article</type><title>Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma</title><source>PubMed (Medline)</source><creator>Pircher, A ; Montali, M ; Berberat, J ; Remonda, L ; Killer, H E</creator><creatorcontrib>Pircher, A ; Montali, M ; Berberat, J ; Remonda, L ; Killer, H E</creatorcontrib><description>Purpose
To investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG).
Patients and methods
Retrospective analysis of medical records of patients with open-angle glaucoma in the period from 2005 to 2015 from the Ophthalmology Department, Cantonal Hospital Aarau, Switzerland was performed. A total of 38 patients (mean age 68.6±11.3 years, 21 females and 17 males) fulfilled the diagnostic criteria of NTG and underwent computed tomography (CT) of the orbit and lumbar puncture (LP). In total, 38 age- and gender-matched Caucasian subjects (mean age: 68.9±10.9 years) without known ON diseases served as controls for ONSD measurements. ONSDs were measured at a distance of 3 mm from the posterior globe and lumbar CSF-p was related to the measurements. Statistical analysis was performed by using the independent two-tailed
t
-test and the non-parametric Spearman's correlation test.
Results
The mean ONSD in NTGs measured 6.4±0.9 mm and in controls 5.4±0.6 mm. The difference between NTGs and controls showed statistical significance (
t
-test:
P
<0.000). The mean CSF-p in NTG was 11.6±3.7 mm Hg. There was no statistical significant correlation between ONSD and CSF-p (Spearman's correlation coefficient
ρ
=0.06,
P
=0.72).
Conclusions
This study demonstrates enlarged ONSDs and normal lumbar CSF-p in 38 Caucasian NTG patients. As enlarged ONSDs generally are associated with increased intracranial CSF-p, these results can be explained by a disturbed communication of CSF-p between the intracranial and intraorbital subarachnoid spaces.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2017.70</identifier><identifier>PMID: 28452990</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/378/1689 ; 631/378/2613 ; 692/420 ; Aged ; Cerebrospinal fluid ; Cerebrospinal Fluid Pressure - physiology ; Clinical Study ; Computed tomography ; European Continental Ancestry Group ; Female ; Glaucoma ; Humans ; Intraocular Pressure - physiology ; Laboratory Medicine ; Low Tension Glaucoma - physiopathology ; Male ; Medical records ; Medicine ; Medicine & Public Health ; Myelin Sheath - pathology ; Ophthalmology ; Optic nerve ; Optic Nerve - diagnostic imaging ; Optic Nerve - pathology ; Pharmaceutical Sciences/Technology ; Pressure ; Retrospective Studies ; Spinal Puncture ; Statistical analysis ; Subarachnoid Space ; Surgery ; Surgical Oncology ; Tomography, X-Ray Computed ; Tonometry, Ocular ; Visual Field Tests ; White people</subject><ispartof>Eye (London), 2017-09, Vol.31 (9), p.1365-1372</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2017</rights><rights>Copyright Nature Publishing Group Sep 2017</rights><rights>Copyright © 2017 Macmillan Publishers Limited, part of Springer Nature. 2017 Macmillan Publishers Limited, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-af7134f5bed5ea3c67f3bf7fb7d4ce4cda29bc54252dc5188fe1c6dad52055e63</citedby><cites>FETCH-LOGICAL-c446t-af7134f5bed5ea3c67f3bf7fb7d4ce4cda29bc54252dc5188fe1c6dad52055e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601451/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601451/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28452990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pircher, A</creatorcontrib><creatorcontrib>Montali, M</creatorcontrib><creatorcontrib>Berberat, J</creatorcontrib><creatorcontrib>Remonda, L</creatorcontrib><creatorcontrib>Killer, H E</creatorcontrib><title>Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG).
Patients and methods
Retrospective analysis of medical records of patients with open-angle glaucoma in the period from 2005 to 2015 from the Ophthalmology Department, Cantonal Hospital Aarau, Switzerland was performed. A total of 38 patients (mean age 68.6±11.3 years, 21 females and 17 males) fulfilled the diagnostic criteria of NTG and underwent computed tomography (CT) of the orbit and lumbar puncture (LP). In total, 38 age- and gender-matched Caucasian subjects (mean age: 68.9±10.9 years) without known ON diseases served as controls for ONSD measurements. ONSDs were measured at a distance of 3 mm from the posterior globe and lumbar CSF-p was related to the measurements. Statistical analysis was performed by using the independent two-tailed
t
-test and the non-parametric Spearman's correlation test.
Results
The mean ONSD in NTGs measured 6.4±0.9 mm and in controls 5.4±0.6 mm. The difference between NTGs and controls showed statistical significance (
t
-test:
P
<0.000). The mean CSF-p in NTG was 11.6±3.7 mm Hg. There was no statistical significant correlation between ONSD and CSF-p (Spearman's correlation coefficient
ρ
=0.06,
P
=0.72).
Conclusions
This study demonstrates enlarged ONSDs and normal lumbar CSF-p in 38 Caucasian NTG patients. As enlarged ONSDs generally are associated with increased intracranial CSF-p, these results can be explained by a disturbed communication of CSF-p between the intracranial and intraorbital subarachnoid spaces.</description><subject>59/57</subject><subject>631/378/1689</subject><subject>631/378/2613</subject><subject>692/420</subject><subject>Aged</subject><subject>Cerebrospinal fluid</subject><subject>Cerebrospinal Fluid Pressure - physiology</subject><subject>Clinical Study</subject><subject>Computed tomography</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Laboratory Medicine</subject><subject>Low Tension Glaucoma - physiopathology</subject><subject>Male</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myelin Sheath - pathology</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Optic Nerve - diagnostic imaging</subject><subject>Optic Nerve - pathology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pressure</subject><subject>Retrospective Studies</subject><subject>Spinal Puncture</subject><subject>Statistical analysis</subject><subject>Subarachnoid Space</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, X-Ray Computed</subject><subject>Tonometry, Ocular</subject><subject>Visual Field Tests</subject><subject>White people</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNptkU1rFTEUhoMo9lpduZeAG0HnmmSSycymIMUvKBREwV3IJGfupMwkY5Jp6Q_wfzeXW0srXZ3F-_Ccw3kRek3JlpK6_QjXsGWEyq0kT9CGctlUggv-FG1IJ0jFGPt9hF6kdEFICSV5jo5YywXrOrJBf3_ApLMLPo1uwT3kKwCP8wg4LNkZ7CFeAk4j6Dxi6_QMGSLW3uJpnXsdsYEIfQxpcV5PeJhWZ_ESIaU1AnYeL8UOPid85YrBhzgXLINPZSfeTXo1YdYv0bNBTwle3c5j9OvL55-n36qz86_fTz-dVYbzJld6kLTmg-jBCtC1aeRQ94Mcemm5AW6sZl1vBGeCWSNo2w5ATWO1FYwIAU19jE4O3mXtZ7CmHBb1pJboZh2vVdBOPUy8G9UuXCrRlN8JWgTvbgUx_FkhZTW7ZGCatIewJkXbrha8pTUp6Nv_0IuwxvKkQnV1K2reSF6o9wfKlB-mCMPdMZSofb2q1Kv29Sq5d765f_8d-6_PAnw4AKlEfgfx3tJHfDfa8LSY</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Pircher, A</creator><creator>Montali, M</creator><creator>Berberat, J</creator><creator>Remonda, L</creator><creator>Killer, H E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma</title><author>Pircher, A ; Montali, M ; Berberat, J ; Remonda, L ; Killer, H E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-af7134f5bed5ea3c67f3bf7fb7d4ce4cda29bc54252dc5188fe1c6dad52055e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>59/57</topic><topic>631/378/1689</topic><topic>631/378/2613</topic><topic>692/420</topic><topic>Aged</topic><topic>Cerebrospinal fluid</topic><topic>Cerebrospinal Fluid Pressure - physiology</topic><topic>Clinical Study</topic><topic>Computed tomography</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Laboratory Medicine</topic><topic>Low Tension Glaucoma - physiopathology</topic><topic>Male</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myelin Sheath - pathology</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Optic Nerve - diagnostic imaging</topic><topic>Optic Nerve - pathology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pressure</topic><topic>Retrospective Studies</topic><topic>Spinal Puncture</topic><topic>Statistical analysis</topic><topic>Subarachnoid Space</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, X-Ray Computed</topic><topic>Tonometry, Ocular</topic><topic>Visual Field Tests</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pircher, A</creatorcontrib><creatorcontrib>Montali, M</creatorcontrib><creatorcontrib>Berberat, J</creatorcontrib><creatorcontrib>Remonda, L</creatorcontrib><creatorcontrib>Killer, H E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pircher, A</au><au>Montali, M</au><au>Berberat, J</au><au>Remonda, L</au><au>Killer, H E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>31</volume><issue>9</issue><spage>1365</spage><epage>1372</epage><pages>1365-1372</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Purpose
To investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG).
Patients and methods
Retrospective analysis of medical records of patients with open-angle glaucoma in the period from 2005 to 2015 from the Ophthalmology Department, Cantonal Hospital Aarau, Switzerland was performed. A total of 38 patients (mean age 68.6±11.3 years, 21 females and 17 males) fulfilled the diagnostic criteria of NTG and underwent computed tomography (CT) of the orbit and lumbar puncture (LP). In total, 38 age- and gender-matched Caucasian subjects (mean age: 68.9±10.9 years) without known ON diseases served as controls for ONSD measurements. ONSDs were measured at a distance of 3 mm from the posterior globe and lumbar CSF-p was related to the measurements. Statistical analysis was performed by using the independent two-tailed
t
-test and the non-parametric Spearman's correlation test.
Results
The mean ONSD in NTGs measured 6.4±0.9 mm and in controls 5.4±0.6 mm. The difference between NTGs and controls showed statistical significance (
t
-test:
P
<0.000). The mean CSF-p in NTG was 11.6±3.7 mm Hg. There was no statistical significant correlation between ONSD and CSF-p (Spearman's correlation coefficient
ρ
=0.06,
P
=0.72).
Conclusions
This study demonstrates enlarged ONSDs and normal lumbar CSF-p in 38 Caucasian NTG patients. As enlarged ONSDs generally are associated with increased intracranial CSF-p, these results can be explained by a disturbed communication of CSF-p between the intracranial and intraorbital subarachnoid spaces.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28452990</pmid><doi>10.1038/eye.2017.70</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Eye (London), 2017-09, Vol.31 (9), p.1365-1372 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5601451 |
| source | PubMed (Medline) |
| subjects | 59/57 631/378/1689 631/378/2613 692/420 Aged Cerebrospinal fluid Cerebrospinal Fluid Pressure - physiology Clinical Study Computed tomography European Continental Ancestry Group Female Glaucoma Humans Intraocular Pressure - physiology Laboratory Medicine Low Tension Glaucoma - physiopathology Male Medical records Medicine Medicine & Public Health Myelin Sheath - pathology Ophthalmology Optic nerve Optic Nerve - diagnostic imaging Optic Nerve - pathology Pharmaceutical Sciences/Technology Pressure Retrospective Studies Spinal Puncture Statistical analysis Subarachnoid Space Surgery Surgical Oncology Tomography, X-Ray Computed Tonometry, Ocular Visual Field Tests White people |
| title | Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma |
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