Preserved immune functionality and high CMV-specific T-cell responses in HIV-infected individuals with poor CD4+ T-cell immune recovery

Poor CD4 + T-cell recovery after cART has been associated with skewed T-cell maturation, inflammation and immunosenescence; however, T-cell functionality in those individuals has not been fully characterized. In the present study, we assessed T-cell function by assessing cytokine production after po...

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Published in:Scientific reports 2017-09, Vol.7 (1), p.11711-13, Article 11711
Main Authors: Gómez-Mora, Elisabet, García, Elisabet, Urrea, Victor, Massanella, Marta, Puig, Jordi, Negredo, Eugenia, Clotet, Bonaventura, Blanco, Julià, Cabrera, Cecilia
Format: Article
Language:English
Subjects:
13/1
13/31
692/699/255/1901
692/699/255/2514
Antiretroviral drugs
CD4 antigen
CD8 antigen
Humanities and Social Sciences
Immune response
Immunosenescence
Interferon
Interleukin 2
Lymphocytes T
Memory cells
multidisciplinary
Science
Science (multidisciplinary)
T cell receptors
γ-Interferon
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Summary:Poor CD4 + T-cell recovery after cART has been associated with skewed T-cell maturation, inflammation and immunosenescence; however, T-cell functionality in those individuals has not been fully characterized. In the present study, we assessed T-cell function by assessing cytokine production after polyclonal, CMV and HIV stimulations of T-cells from ART-suppressed HIV-infected individuals with CD4 + T-cell counts >350 cells/μL (immunoconcordants) or
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-12013-2