Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity

• Published in: Disease markers 2017-01, Vol.2017 (2017), p.1-8
• Main Authors: Cabello, Giselda Maria Kalil, Cabello, Pedro Hernan, Carneiro, João Regis Ivar, Ramos, Vivianne Galante, Campos Junior, Mário, Zembrzuski, Verônica Marques, Martins, Raisa da Silva, Ochioni, Alan Cleveland, Fonseca, Ana Carolina Proença da, Nogueira Neto, José Firmino
• Format: Article
• Language: English
• Subjects: Adiponectin; Adiponectin - genetics; Adult; Association analysis; Body mass; Body mass index; Body size; Body weight; Case-Control Studies; Chemokines - genetics; Eutrophication; Female; Gene Frequency; Gene polymorphism; Genetic factors; Genotypes; Humans; Intercellular Signaling Peptides and Proteins - genetics; Male; Middle Aged; Obesity; Obesity - genetics; Polymorphism; Polymorphism, Single Nucleotide; Retinoic acid; Risk factors; Single-nucleotide polymorphism; Transcription Factors - genetics
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2017/5289120

Obesity is the most common nutritional disorder. This disease is a multifactorial disease influenced by environmental and genetic factors. This study investigated the relationship between common variants of adiponectin (ADIPOQ), retinoic acid receptor responder 2 (RARRES2), and peroxisome proliferator-activated receptor-γ coativator-1 (PPARGC1) and obesity-related traits and susceptibility. A total of 167 individuals with obesity and 165 normal-weight subjects were recruited. Genotype frequencies of rs182052 in ADIPOQ differed significantly between the groups. Genotype AA was observed at a higher frequency in case than in control subjects. Association analysis showed that the A allele was a risk factor for obesity. This polymorphism was associated with body weight, body mass index (BMI), and waist circumference. After stratification by BMI, eutrophic individuals with AA or AG genotypes had higher body weights and waist circumferences than those with GG genotypes. In the case group, no associations were observed, except for stratified subjects with morbid obesity that exhibited a progressive increase of body weight, BMI, and waist circumference when rs182052 A was present. No associations were observed between SNPs in RARRES2 and PPARGC1 and obesity or any other studied variables. The rs182052 polymorphism in ADIPOQ is associated with a higher risk for obesity and obesity-related parameters.