The efficacy of tranexamic acid in reducing blood loss in total shoulder arthroplasty: A meta-analysis

The purpose of this meta-analysis is to compare the efficacy of tranexamic acid (TXA) versus placebo after a total shoulder arthroplasty (TSA). In April 2017, a systematic computer-based search was conducted in the databases of PubMed, Embase, Web of Science, Cochrane Library, and Google. Studies co...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-09, Vol.96 (37), p.e7880-e7880
Main Authors: He, Jing, Wang, Xi-e, Yuan, Guo-Hong, Zhang, Lian-Hai
Format: Article
Language:English
Subjects:
Antifibrinolytic Agents - therapeutic use
Arthroplasty, Replacement, Shoulder
Blood Loss, Surgical - prevention & control
Humans
Systematic Review and Meta-Analysis
Tranexamic Acid - therapeutic use
Treatment Outcome
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Summary:The purpose of this meta-analysis is to compare the efficacy of tranexamic acid (TXA) versus placebo after a total shoulder arthroplasty (TSA). In April 2017, a systematic computer-based search was conducted in the databases of PubMed, Embase, Web of Science, Cochrane Library, and Google. Studies comparing TXA versus placebo in reducing blood loss after TSA were included. The endpoints were the need for transfusion, blood loss in drainage, hemoglobin drop, and total blood loss. Stata 12.0 software was used for the meta-analysis. Six studies involving a total of 637 patients met the inclusion criteria. The meta-analysis revealed that, compared with control groups, treatment with TXA could decrease the need for transfusion (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000007880