SYNTAX score based on coronary computed tomography angiography may have a prognostic value in patients with complex coronary artery disease: An observational study from a retrospective cohort

The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score is an invasive coronary angiography (ICA)-based score for quantifying the complexity of coronary artery disease (CAD). Although the SYNTAX score was originally developed based on ICA, recent publicat...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-09, Vol.96 (37), p.e7999-e7999
Main Authors: Suh, Young Joo, Han, Kyunghwa, Chang, Suyon, Kim, Jin Young, Im, Dong Jin, Hong, Yoo Jin, Lee, Hye-Jeong, Hur, Jin, Kim, Young Jin, Choi, Byoung Wook
Format: Article
Language:English
Subjects:
Aged
Cerebrovascular Disorders - epidemiology
Combined Modality Therapy
Computed Tomography Angiography
Coronary Angiography - methods
Coronary Artery Bypass
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - therapy
Drug-Eluting Stents
Female
Heart Diseases - epidemiology
Humans
Male
Observational Study
Paclitaxel - administration & dosage
Percutaneous Coronary Intervention
Postoperative Complications - epidemiology
Predictive Value of Tests
Prognosis
Retrospective Studies
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Summary:The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score is an invasive coronary angiography (ICA)-based score for quantifying the complexity of coronary artery disease (CAD). Although the SYNTAX score was originally developed based on ICA, recent publications have reported that coronary computed tomography angiography (CCTA) is a feasible modality for the estimation of the SYNTAX score.The aim of our study was to investigate the prognostic value of the SYNTAX score, based on CCTA for the prediction of major adverse cardiac and cerebrovascular events (MACCEs) in patients with complex CAD.The current study was approved by the institutional review board of our institution, and informed consent was waived for this retrospective cohort study. We included 251 patients (173 men, mean age 66.0 ± 9.29 years) who had complex CAD [3-vessel disease or left main (LM) disease] on CCTA. SYNTAX score was obtained on the basis of CCTA. Follow-up clinical outcome data regarding composite MACCEs were also obtained. Cox proportional hazards models were developed to predict the risk of MACCEs based on clinical variables, treatment, and computed tomography (CT)-SYNTAX scores.During the median follow-up period of 1517 days, there were 48 MACCEs. Univariate Cox hazards models demonstrated that MACCEs were associated with advanced age, low body mass index (BMI), and dyslipidemia (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000007999