Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

• Published in: Frontiers in neuroendocrinology 2017-10, Vol.47, p.123-133
• Main Author: Rosenfeld, Cheryl S.
• Format: Article
• Language: English
• Subjects: Animals; Behavior; Benzhydryl Compounds - toxicity; BPA; Brain; Developmental; DOHaD; EDC; Endocrine Disruptors - toxicity; Environment; Estrogen; Models, Animal; Neurosecretory Systems - drug effects; Phenols - toxicity; Plastic; Sulfones - toxicity
• ISSN: 0091-3022; 1095-6808
• DOI: 10.1016/j.yfrne.2017.08.001

•Bisphenol A (BPA) can lead to neurobehavioral disorders in animal models and humans.•Need to identify possible safer chemical alternatives to BPA.•BPS, BPF, and BPAF are currently being used as potential alternatives to BPA.•Studies suggest these other bisphenols induce neuroendocrine disruptive effects.•These other bisphenols may induce some of their actions via estrogen receptors. Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes. In the past few years, several animal studies have shown exposure to these other bisphenols induce similar neurobehavioral disruption as BPA. We will explore in this review article the current studies suggesting these other bisphenols result in neuroendocrine disruptions that may be estrogen receptor-dependent. Current work may aide in designing future studies to test further whether these BPA-substitutes can act as neuroendocrine disruptors.