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The Impact of the Eda Pathway on Tooth Root Development
The Eda pathway (Eda, Edar, Edaradd) plays an important role in tooth development, determining tooth number, crown shape, and enamel formation. Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig’s epithelial root sheath (HERS) dur...
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Published in: | Journal of dental research 2017-10, Vol.96 (11), p.1290-1297 |
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description | The Eda pathway (Eda, Edar, Edaradd) plays an important role in tooth development, determining tooth number, crown shape, and enamel formation. Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig’s epithelial root sheath (HERS) during root development, with mutant mice showing a high incidence of taurodontism: large pulp chambers lacking or showing delayed bifurcation or trifurcation of the roots. The mouse upper second molars in the Eda pathway mutants show the highest incidence of taurodontism, this enhanced susceptibility being matched in human patients with mutations in EDA-A1. These taurodont teeth form due to defects in the direction of extension of the HERS from the crown, associated with a more extensive area of proliferation of the neighboring root mesenchyme. In those teeth where the angle at which the HERS extends from the crown is very wide and therefore more vertical, the mutant HERSs fail to reach toward the center of the tooth in the normal furcation region, and taurodont teeth are created. The phenotype is variable, however, with milder changes in angle and proliferation leading to normal or delayed furcation. This is the first analysis of the role of Eda in the root, showing a direct role for this pathway during postnatal mouse development, and it suggests that changes in proliferation and angle of HERS may underlie taurodontism in a range of syndromes. |
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Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig’s epithelial root sheath (HERS) during root development, with mutant mice showing a high incidence of taurodontism: large pulp chambers lacking or showing delayed bifurcation or trifurcation of the roots. The mouse upper second molars in the Eda pathway mutants show the highest incidence of taurodontism, this enhanced susceptibility being matched in human patients with mutations in EDA-A1. These taurodont teeth form due to defects in the direction of extension of the HERS from the crown, associated with a more extensive area of proliferation of the neighboring root mesenchyme. In those teeth where the angle at which the HERS extends from the crown is very wide and therefore more vertical, the mutant HERSs fail to reach toward the center of the tooth in the normal furcation region, and taurodont teeth are created. The phenotype is variable, however, with milder changes in angle and proliferation leading to normal or delayed furcation. This is the first analysis of the role of Eda in the root, showing a direct role for this pathway during postnatal mouse development, and it suggests that changes in proliferation and angle of HERS may underlie taurodontism in a range of syndromes.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/0022034517725692</identifier><identifier>PMID: 28813629</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adapter proteins ; Adolescent ; Animals ; Child ; Defects ; Dental enamel ; Dental pulp ; Dental Pulp Cavity - abnormalities ; Dental roots ; Dentistry ; Ectodysplasins - genetics ; Enamel ; Humans ; Ligands ; Male ; Mesenchyme ; Mice ; Molar - abnormalities ; Molar - embryology ; Molars ; Mutation ; Odontogenesis - genetics ; Phenotype ; Phenotypes ; R&D ; Research & development ; Research Reports ; Signal Transduction ; Teeth ; Tooth Abnormalities - genetics ; Tooth Root - abnormalities ; Tooth Root - embryology ; X-Ray Microtomography</subject><ispartof>Journal of dental research, 2017-10, Vol.96 (11), p.1290-1297</ispartof><rights>International & American Associations for Dental Research 2017</rights><rights>International & American Associations for Dental Research 2017 2017 International & American Associations for Dental Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-ee9726a72e61e193b0a60433ddd4dd89dd9c4cb88d5705c53df9fbdfeb72dee23</citedby><cites>FETCH-LOGICAL-c420t-ee9726a72e61e193b0a60433ddd4dd89dd9c4cb88d5705c53df9fbdfeb72dee23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28813629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fons Romero, J.M.</creatorcontrib><creatorcontrib>Star, H.</creatorcontrib><creatorcontrib>Lav, R.</creatorcontrib><creatorcontrib>Watkins, S.</creatorcontrib><creatorcontrib>Harrison, M.</creatorcontrib><creatorcontrib>Hovorakova, M.</creatorcontrib><creatorcontrib>Headon, D.</creatorcontrib><creatorcontrib>Tucker, A.S.</creatorcontrib><title>The Impact of the Eda Pathway on Tooth Root Development</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>The Eda pathway (Eda, Edar, Edaradd) plays an important role in tooth development, determining tooth number, crown shape, and enamel formation. Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig’s epithelial root sheath (HERS) during root development, with mutant mice showing a high incidence of taurodontism: large pulp chambers lacking or showing delayed bifurcation or trifurcation of the roots. The mouse upper second molars in the Eda pathway mutants show the highest incidence of taurodontism, this enhanced susceptibility being matched in human patients with mutations in EDA-A1. These taurodont teeth form due to defects in the direction of extension of the HERS from the crown, associated with a more extensive area of proliferation of the neighboring root mesenchyme. In those teeth where the angle at which the HERS extends from the crown is very wide and therefore more vertical, the mutant HERSs fail to reach toward the center of the tooth in the normal furcation region, and taurodont teeth are created. The phenotype is variable, however, with milder changes in angle and proliferation leading to normal or delayed furcation. This is the first analysis of the role of Eda in the root, showing a direct role for this pathway during postnatal mouse development, and it suggests that changes in proliferation and angle of HERS may underlie taurodontism in a range of syndromes.</description><subject>Adapter proteins</subject><subject>Adolescent</subject><subject>Animals</subject><subject>Child</subject><subject>Defects</subject><subject>Dental enamel</subject><subject>Dental pulp</subject><subject>Dental Pulp Cavity - abnormalities</subject><subject>Dental roots</subject><subject>Dentistry</subject><subject>Ectodysplasins - genetics</subject><subject>Enamel</subject><subject>Humans</subject><subject>Ligands</subject><subject>Male</subject><subject>Mesenchyme</subject><subject>Mice</subject><subject>Molar - abnormalities</subject><subject>Molar - embryology</subject><subject>Molars</subject><subject>Mutation</subject><subject>Odontogenesis - genetics</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>R&D</subject><subject>Research & development</subject><subject>Research Reports</subject><subject>Signal Transduction</subject><subject>Teeth</subject><subject>Tooth Abnormalities - genetics</subject><subject>Tooth Root - abnormalities</subject><subject>Tooth Root - embryology</subject><subject>X-Ray Microtomography</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kctLxDAQxoMouq7ePUnBi5fq5NE2uQjiGxYUWc8hbaa20jZr01X8782y6_oAL0mG-c03M_kIOaBwQmmWnQIwBlwk4c2SVLENMqKJEDEkim6S0SIdL_I7ZNf7FwCqmOTbZIdJSXnK1Ihk0wqju3ZmiiFyZTSE6Mqa6MEM1bv5iFwXTZ0bqugxnNElvmHjZi12wx7ZKk3jcX91j8nT9dX04jae3N_cXZxP4kIwGGJElbHUZAxTilTxHEwKgnNrrbBWKmtVIYpcSptkkBQJt6Uqc1tinjGLyPiYnC11Z_O8RVuE1r1p9KyvW9N_aGdq_TvT1ZV-dm86SSmXkgeB45VA717n6Afd1r7ApjEdurnXYShGhQCQAT36g764ed-F9TTjAOnir7NAwZIqeud9j-V6GAp64Yr-60ooOfy5xLrgy4YAxEvAm2f87vqv4CeO6ZOO</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Fons Romero, J.M.</creator><creator>Star, H.</creator><creator>Lav, R.</creator><creator>Watkins, S.</creator><creator>Harrison, M.</creator><creator>Hovorakova, M.</creator><creator>Headon, D.</creator><creator>Tucker, A.S.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171001</creationdate><title>The Impact of the Eda Pathway on Tooth Root Development</title><author>Fons Romero, J.M. ; Star, H. ; Lav, R. ; Watkins, S. ; Harrison, M. ; Hovorakova, M. ; Headon, D. ; Tucker, A.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-ee9726a72e61e193b0a60433ddd4dd89dd9c4cb88d5705c53df9fbdfeb72dee23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adapter proteins</topic><topic>Adolescent</topic><topic>Animals</topic><topic>Child</topic><topic>Defects</topic><topic>Dental enamel</topic><topic>Dental pulp</topic><topic>Dental Pulp Cavity - abnormalities</topic><topic>Dental roots</topic><topic>Dentistry</topic><topic>Ectodysplasins - genetics</topic><topic>Enamel</topic><topic>Humans</topic><topic>Ligands</topic><topic>Male</topic><topic>Mesenchyme</topic><topic>Mice</topic><topic>Molar - abnormalities</topic><topic>Molar - embryology</topic><topic>Molars</topic><topic>Mutation</topic><topic>Odontogenesis - genetics</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>R&D</topic><topic>Research & development</topic><topic>Research Reports</topic><topic>Signal Transduction</topic><topic>Teeth</topic><topic>Tooth Abnormalities - genetics</topic><topic>Tooth Root - abnormalities</topic><topic>Tooth Root - embryology</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fons Romero, J.M.</creatorcontrib><creatorcontrib>Star, H.</creatorcontrib><creatorcontrib>Lav, R.</creatorcontrib><creatorcontrib>Watkins, S.</creatorcontrib><creatorcontrib>Harrison, M.</creatorcontrib><creatorcontrib>Hovorakova, M.</creatorcontrib><creatorcontrib>Headon, D.</creatorcontrib><creatorcontrib>Tucker, A.S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fons Romero, J.M.</au><au>Star, H.</au><au>Lav, R.</au><au>Watkins, S.</au><au>Harrison, M.</au><au>Hovorakova, M.</au><au>Headon, D.</au><au>Tucker, A.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of the Eda Pathway on Tooth Root Development</atitle><jtitle>Journal of dental research</jtitle><addtitle>J Dent Res</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>96</volume><issue>11</issue><spage>1290</spage><epage>1297</epage><pages>1290-1297</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><abstract>The Eda pathway (Eda, Edar, Edaradd) plays an important role in tooth development, determining tooth number, crown shape, and enamel formation. Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig’s epithelial root sheath (HERS) during root development, with mutant mice showing a high incidence of taurodontism: large pulp chambers lacking or showing delayed bifurcation or trifurcation of the roots. The mouse upper second molars in the Eda pathway mutants show the highest incidence of taurodontism, this enhanced susceptibility being matched in human patients with mutations in EDA-A1. These taurodont teeth form due to defects in the direction of extension of the HERS from the crown, associated with a more extensive area of proliferation of the neighboring root mesenchyme. In those teeth where the angle at which the HERS extends from the crown is very wide and therefore more vertical, the mutant HERSs fail to reach toward the center of the tooth in the normal furcation region, and taurodont teeth are created. The phenotype is variable, however, with milder changes in angle and proliferation leading to normal or delayed furcation. This is the first analysis of the role of Eda in the root, showing a direct role for this pathway during postnatal mouse development, and it suggests that changes in proliferation and angle of HERS may underlie taurodontism in a range of syndromes.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28813629</pmid><doi>10.1177/0022034517725692</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adapter proteins Adolescent Animals Child Defects Dental enamel Dental pulp Dental Pulp Cavity - abnormalities Dental roots Dentistry Ectodysplasins - genetics Enamel Humans Ligands Male Mesenchyme Mice Molar - abnormalities Molar - embryology Molars Mutation Odontogenesis - genetics Phenotype Phenotypes R&D Research & development Research Reports Signal Transduction Teeth Tooth Abnormalities - genetics Tooth Root - abnormalities Tooth Root - embryology X-Ray Microtomography |
title | The Impact of the Eda Pathway on Tooth Root Development |
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