Self-reported oral health and quality of life of postmenopausal breast cancer survivors on aromatase inhibitors and women without cancer diagnoses: a longitudinal analysis

Introduction Aromatase inhibitors (AIs) are a well-established component of adjuvant therapy in postmenopausal women with hormone receptor (HR) + early stage breast cancer (BCa). We explored in an 18-month cohort study whether subjective oral health (OH), subjective periodontal health (PH), and oral...

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Published in:Supportive care in cancer 2016-11, Vol.24 (11), p.4815-4824
Main Authors: Taichman, L. Susan, Van Poznak, Catherine H., Inglehart, Marita R.
Format: Article
Language:English
Subjects:
Aromatase Inhibitors - pharmacology
Aromatase Inhibitors - therapeutic use
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Cohort Studies
Dental health
Female
Humans
Medicine
Medicine & Public Health
Middle Aged
Nursing
Nursing Research
Oncology
Oral diseases
Oral Health - standards
Oral hygiene
Original Article
Pain Medicine
Postmenopause
Quality of life
Quality of Life - psychology
Rehabilitation Medicine
Self Report
Survivors
Tumors
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creator Taichman, L. Susan
Van Poznak, Catherine H.
Inglehart, Marita R.
description Introduction Aromatase inhibitors (AIs) are a well-established component of adjuvant therapy in postmenopausal women with hormone receptor (HR) + early stage breast cancer (BCa). We explored in an 18-month cohort study whether subjective oral health (OH), subjective periodontal health (PH), and oral health-related quality of life (OHRQoL) of postmenopausal BCa survivors on AIs differ from those of women without cancer diagnoses, and whether saliva flow, OH, PH, and OHRQoL are related. Methods Data were collected from 29 postmenopausal BCa survivors on AIs and 29 postmenopausal women without cancer diagnoses. Socio-demographic information, OH, PH, and OHRQoL were collected at baseline and 6, 12, and 18 months later. Unstimulated whole saliva volume per 15 min was determined by drooling. Results The two groups did not differ in background characteristics at baseline. Women on AIs had poorer OH ( p  = .043), PH ( p  = .04), and OHRQoL ( p  = .017), and lower saliva flow rate ( p  
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Susan ; Van Poznak, Catherine H. ; Inglehart, Marita R.</creator><creatorcontrib>Taichman, L. Susan ; Van Poznak, Catherine H. ; Inglehart, Marita R.</creatorcontrib><description>Introduction Aromatase inhibitors (AIs) are a well-established component of adjuvant therapy in postmenopausal women with hormone receptor (HR) + early stage breast cancer (BCa). We explored in an 18-month cohort study whether subjective oral health (OH), subjective periodontal health (PH), and oral health-related quality of life (OHRQoL) of postmenopausal BCa survivors on AIs differ from those of women without cancer diagnoses, and whether saliva flow, OH, PH, and OHRQoL are related. Methods Data were collected from 29 postmenopausal BCa survivors on AIs and 29 postmenopausal women without cancer diagnoses. Socio-demographic information, OH, PH, and OHRQoL were collected at baseline and 6, 12, and 18 months later. Unstimulated whole saliva volume per 15 min was determined by drooling. Results The two groups did not differ in background characteristics at baseline. Women on AIs had poorer OH ( p  = .043), PH ( p  = .04), and OHRQoL ( p  = .017), and lower saliva flow rate ( p  &lt; .001) than control respondents. BCa survivors had the poorest PH at the 18-month visit. Xerostomia was correlated with OH at baseline and with OH and PH at 18 months. However, objective saliva flow rate was not correlated with OH or OHRQoL at this visit. Conclusions This study is the first to investigate the effects of AIs on patients’ subjective OH, subjective PH, and OHRQoL. The data suggest that women treated with AIs have worse OH, PH, and OHRQoL than women without cancer diagnoses. Interprofessional care is recommended so that women on AIs receive optimal supportive oral care to assure long-term OH and positive OHRQoL. Trial registration ClinicalTrials.gov NCT01272570 https://clinicaltrials.gov/ct2/show/NCT01272570 .</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-016-3336-6</identifier><identifier>PMID: 27455851</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aromatase Inhibitors - pharmacology ; Aromatase Inhibitors - therapeutic use ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Cohort Studies ; Dental health ; Female ; Humans ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Nursing ; Nursing Research ; Oncology ; Oral diseases ; Oral Health - standards ; Oral hygiene ; Original Article ; Pain Medicine ; Postmenopause ; Quality of life ; Quality of Life - psychology ; Rehabilitation Medicine ; Self Report ; Survivors ; Tumors</subject><ispartof>Supportive care in cancer, 2016-11, Vol.24 (11), p.4815-4824</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-2ad66b2ba78de9028b9eb2181f7db0675d07e1643c88d1442cb345aa8f71d7803</citedby><cites>FETCH-LOGICAL-c470t-2ad66b2ba78de9028b9eb2181f7db0675d07e1643c88d1442cb345aa8f71d7803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1822043841/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1822043841?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,21394,21395,27924,27925,33611,33612,34530,34531,43733,44115,74221,74639</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27455851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taichman, L. Susan</creatorcontrib><creatorcontrib>Van Poznak, Catherine H.</creatorcontrib><creatorcontrib>Inglehart, Marita R.</creatorcontrib><title>Self-reported oral health and quality of life of postmenopausal breast cancer survivors on aromatase inhibitors and women without cancer diagnoses: a longitudinal analysis</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Introduction Aromatase inhibitors (AIs) are a well-established component of adjuvant therapy in postmenopausal women with hormone receptor (HR) + early stage breast cancer (BCa). We explored in an 18-month cohort study whether subjective oral health (OH), subjective periodontal health (PH), and oral health-related quality of life (OHRQoL) of postmenopausal BCa survivors on AIs differ from those of women without cancer diagnoses, and whether saliva flow, OH, PH, and OHRQoL are related. Methods Data were collected from 29 postmenopausal BCa survivors on AIs and 29 postmenopausal women without cancer diagnoses. Socio-demographic information, OH, PH, and OHRQoL were collected at baseline and 6, 12, and 18 months later. Unstimulated whole saliva volume per 15 min was determined by drooling. Results The two groups did not differ in background characteristics at baseline. Women on AIs had poorer OH ( p  = .043), PH ( p  = .04), and OHRQoL ( p  = .017), and lower saliva flow rate ( p  &lt; .001) than control respondents. BCa survivors had the poorest PH at the 18-month visit. Xerostomia was correlated with OH at baseline and with OH and PH at 18 months. However, objective saliva flow rate was not correlated with OH or OHRQoL at this visit. Conclusions This study is the first to investigate the effects of AIs on patients’ subjective OH, subjective PH, and OHRQoL. The data suggest that women treated with AIs have worse OH, PH, and OHRQoL than women without cancer diagnoses. Interprofessional care is recommended so that women on AIs receive optimal supportive oral care to assure long-term OH and positive OHRQoL. Trial registration ClinicalTrials.gov NCT01272570 https://clinicaltrials.gov/ct2/show/NCT01272570 .</description><subject>Aromatase Inhibitors - pharmacology</subject><subject>Aromatase Inhibitors - therapeutic use</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Cohort Studies</subject><subject>Dental health</subject><subject>Female</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Oral diseases</subject><subject>Oral Health - standards</subject><subject>Oral hygiene</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Postmenopause</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Rehabilitation Medicine</subject><subject>Self Report</subject><subject>Survivors</subject><subject>Tumors</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>HEHIP</sourceid><sourceid>M2R</sourceid><sourceid>M2S</sourceid><recordid>eNp1ks9u1DAQxiMEotvCA3BBlrhwCfhvnOWAhCoKSJU4AGdrEk82rrL21na22mfiJXHYsipIXDyS5zffzNhfVb1g9A2jVL9NlCpOa8qaWgjR1M2jasWkELUWYv24WtG1ZLUUSp1V5yndUMq0Vvxpdca1VKpVbFX9_IbTUEfchZjRkhBhIiPClEcC3pLbGSaXDyQMZHIDLnEXUt6iDzuYU4G7iJAy6cH3GEma497tQ0wkeAIxbCFDQuL86DqXl_tF9S4UAXLn8hjmU6l1sPEhYXpHgEzBb1yerfOlBZTjkFx6Vj0ZYEr4_D5eVD-uPn6__Fxff_305fLDdd1LTXPNwTZNxzvQrcU15W23xo6zlg3adrTRylKNrJGib1vLpOR9J6QCaAfNrG6puKjeH3V3c7dF26PP5VnMLrotxIMJ4MzfGe9Gswl7oxpWJpBF4PW9QAy3M6Zsti71OE3gMczJsJYLKqhaL71e_YPehDmWhX9TvIi1khWKHak-hpQiDqdhGDWLFczRCqZYwSxWME2peflwi1PFn78vAD8CqaT8BuOD1v9V_QXdbcPO</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Taichman, L. Susan</creator><creator>Van Poznak, Catherine H.</creator><creator>Inglehart, Marita R.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161101</creationdate><title>Self-reported oral health and quality of life of postmenopausal breast cancer survivors on aromatase inhibitors and women without cancer diagnoses: a longitudinal analysis</title><author>Taichman, L. 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Susan</au><au>Van Poznak, Catherine H.</au><au>Inglehart, Marita R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-reported oral health and quality of life of postmenopausal breast cancer survivors on aromatase inhibitors and women without cancer diagnoses: a longitudinal analysis</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>24</volume><issue>11</issue><spage>4815</spage><epage>4824</epage><pages>4815-4824</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Introduction Aromatase inhibitors (AIs) are a well-established component of adjuvant therapy in postmenopausal women with hormone receptor (HR) + early stage breast cancer (BCa). We explored in an 18-month cohort study whether subjective oral health (OH), subjective periodontal health (PH), and oral health-related quality of life (OHRQoL) of postmenopausal BCa survivors on AIs differ from those of women without cancer diagnoses, and whether saliva flow, OH, PH, and OHRQoL are related. Methods Data were collected from 29 postmenopausal BCa survivors on AIs and 29 postmenopausal women without cancer diagnoses. Socio-demographic information, OH, PH, and OHRQoL were collected at baseline and 6, 12, and 18 months later. Unstimulated whole saliva volume per 15 min was determined by drooling. Results The two groups did not differ in background characteristics at baseline. Women on AIs had poorer OH ( p  = .043), PH ( p  = .04), and OHRQoL ( p  = .017), and lower saliva flow rate ( p  &lt; .001) than control respondents. BCa survivors had the poorest PH at the 18-month visit. Xerostomia was correlated with OH at baseline and with OH and PH at 18 months. However, objective saliva flow rate was not correlated with OH or OHRQoL at this visit. Conclusions This study is the first to investigate the effects of AIs on patients’ subjective OH, subjective PH, and OHRQoL. The data suggest that women treated with AIs have worse OH, PH, and OHRQoL than women without cancer diagnoses. Interprofessional care is recommended so that women on AIs receive optimal supportive oral care to assure long-term OH and positive OHRQoL. Trial registration ClinicalTrials.gov NCT01272570 https://clinicaltrials.gov/ct2/show/NCT01272570 .</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27455851</pmid><doi>10.1007/s00520-016-3336-6</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Aromatase Inhibitors - pharmacology
Aromatase Inhibitors - therapeutic use
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Cohort Studies
Dental health
Female
Humans
Medicine
Medicine & Public Health
Middle Aged
Nursing
Nursing Research
Oncology
Oral diseases
Oral Health - standards
Oral hygiene
Original Article
Pain Medicine
Postmenopause
Quality of life
Quality of Life - psychology
Rehabilitation Medicine
Self Report
Survivors
Tumors
title Self-reported oral health and quality of life of postmenopausal breast cancer survivors on aromatase inhibitors and women without cancer diagnoses: a longitudinal analysis
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